Bastami Farshid, Shahab Shahriar, Parsa Azin, Abbas Fatemeh Mashhadi, Noori Kooshki Mohammad Hadi, Namdari Mahshid, Lisar Hamidreza Azimi, Rafiei Tohid, Fahimipour Farahnaz, Salehi Majid, Jafari Maissa
Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahed University, Tehran, Iran.
Oral Maxillofac Surg. 2018 Mar;22(1):13-20. doi: 10.1007/s10006-017-0657-7. Epub 2017 Oct 31.
The main aim of this study was to investigate whether Hounsfield unit derived from computed tomography (HU/CT) and gray value derived from cone beam computed tomography (GV/CBCT) can predict the amount of new bone formation (NBF) in the defects after bone reconstruction surgeries.
Thirty calvaria defects created in 5 rabbits and grafted with both radiolucent (RL, n = 15) and radiopaque (RO, n = 15) bone substitute materials were evaluated, 8 weeks postoperatively. The defects were scanned by multislice computed tomography (Somatom®, Siemens Healthineers, Erlangen, Germany) and CBCT (NewTom VG®, Qualitative Radiology, Verona, Italy). MSCT and CBCT scans were matched to select the exact region of interest (ROI, diameter = 5 mm and height = 1 mm). HU/CT and GV/CBCT of each ROI were obtained. Mean amount of NBF in whole of the defects was measured using serial histomorphometric assessment. We investigated the correlation between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF generally, and separately among the RL or RO grafted defects, by linear generalized estimating equation modeling. Receiver operation characteristic analysis was performed to check the accuracy of HU/CT and GV/CBCT in diagnosing more than 10% NBF in the samples.
There were linear correlations between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF.
According to the results, both HU/CT and GV/CBCT can be considered as fairly good predictors for assessment of the amount of NBF following bone reconstruction surgeries.
本研究的主要目的是调查计算机断层扫描得出的亨氏单位（HU/CT）和锥形束计算机断层扫描得出的灰度值（GV/CBCT）能否预测骨重建手术后缺损处的新骨形成量（NBF）。
在5只兔子身上制造30个颅骨缺损，并用透光（RL，n = 15）和不透光（RO，n = 15）骨替代材料进行移植，术后8周进行评估。通过多层计算机断层扫描（Somatom®，西门子医疗，德国埃尔朗根）和CBCT（NewTom VG®，Qualitative Radiology，意大利维罗纳）对缺损进行扫描。匹配MSCT和CBCT扫描以选择精确的感兴趣区域（ROI，直径 = 5毫米，高度 = 1毫米）。获取每个ROI的HU/CT和GV/CBCT。使用系列组织形态计量学评估测量整个缺损处的NBF平均量。我们通过线性广义估计方程建模，总体上以及分别在RL或RO移植缺损中，研究了HU/CT与GV/CBCT、HU/CT与NBF以及GV/CBCT与NBF之间的相关性。进行了受试者操作特征分析，以检查HU/CT和GV/CBCT在诊断样本中NBF超过10%时的准确性。
HU/CT与GV/CBCT、HU/CT与NBF以及GV/CBCT与NBF之间存在线性相关性。
根据结果，HU/CT和GV/CBCT均可被视为评估骨重建手术后NBF量的相当好的预测指标。
