Peptide Chemistry Research Center, K. N. Toosi University of Technology , P.O. Box 15875-4416, Tehran, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences , Kermanshah, Iran.
Org Lett. 2017 Nov 17;19(22):6124-6127. doi: 10.1021/acs.orglett.7b02603. Epub 2017 Oct 31.
An efficient approach for the synthesis of pyranoquinolines through the indium-catalyzed activation of alkynes is reported. Intramolecular hydroamidation of alkynes can proceed through alkyne activation by indium(III) and then 6-exo-dig cyclization, leading to a fused pyran ring with high selectivity, high atom economy, and good to excellent yields. The cyclization was accomplished through the oxygen, not the nitrogen, of the amide functional group.
报道了一种通过铟催化炔烃活化来合成吡喃并喹啉的有效方法。炔烃的分子内氨氢化可以通过三价铟活化炔烃，然后进行 6-endo-dig 环化反应来进行，从而以高选择性、高原子经济性和良好至优异的收率得到稠合的吡喃环。环化反应是通过酰胺官能团的氧原子而不是氮原子完成的。
