工程噬菌体纳米纤维诱导血管生成。

Engineered phage nanofibers induce angiogenesis.

机构信息

BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of Korea.

出版信息

Nanoscale. 2017 Nov 9;9(43):17109-17117. doi: 10.1039/c7nr03332j.

Abstract

Herein, we exploited a bioinspired M13 bacteriophage as an angiogenic nanofiber for soft tissue engineering applications. We demonstrated that engineered phage nanofibers induce angiogenesis with specific biochemical and topological cues. Specifically, nanofibrous phage structures provided a novel therapeutic platform for stem cell technologies in ischemic diseases.

摘要

在这里，我们利用一种受生物启发的 M13 噬菌体作为一种血管生成纳米纤维，用于软组织工程应用。我们证明了工程化的噬菌体纳米纤维通过特定的生化和拓扑线索诱导血管生成。具体来说，纳米纤维状噬菌体结构为缺血性疾病中的干细胞技术提供了一种新的治疗平台。