Shrestha Kshitiz Raj, Yoo So Young
BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Stem Cells Int. 2019 Apr 3;2019:4038560. doi: 10.1155/2019/4038560. eCollection 2019.
Self-renewal and differentiation of stem cells can be the best option for treating intractable diseases in regenerative medicine, and they occur when these cells reside in a special microenvironment, called the "stem cell niche." Thus, the niche is crucial for the effective performance of the stem cells in both and since the niche provides its functional cues by interacting with stem cells chemically, physically, or topologically. This review provides a perspective on the different types of artificial niches including engineered phage and how they could be used to recapitulate or manipulate stem cell niches. Phage-based artificial niche engineering as a promising therapeutic strategy for repair and regeneration of tissues is also discussed.
干细胞的自我更新和分化可能是再生医学中治疗疑难疾病的最佳选择，而当这些细胞存在于一种特殊的微环境（称为“干细胞生态位”）中时，就会发生自我更新和分化。因此，生态位对于干细胞在再生医学和组织工程中的有效发挥作用至关重要，因为生态位通过与干细胞进行化学、物理或拓扑学相互作用来提供其功能线索。本综述提供了关于不同类型人工生态位（包括工程噬菌体）的观点，以及它们如何用于重现或操纵干细胞生态位。还讨论了基于噬菌体的人工生态位工程作为一种有前景的组织修复和再生治疗策略。
