感染埃博拉病毒或雷斯顿病毒的人源化小鼠的疾病严重程度与肝脏中早期病毒复制的程度有关。
Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.
机构信息
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.
Rocky Mountain Veterinary Branch.
出版信息
J Infect Dis. 2017 Dec 27;217(1):58-63. doi: 10.1093/infdis/jix562.
Abstract
Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage and disease were observed exclusively in EBOV-infected mice. These abnormalities were associated with significantly higher EBOV replication in the liver but not in the spleen, suggesting that in this model, efficiency of viral replication in select tissues early in infection may contribute to differences in viral pathogenicity.
摘要
埃博拉病毒（EBOV）和雷斯顿病毒（RESTV）均可使非人类灵长类动物发病，但只有 EBOV 可使人类发病。为了研究病毒致病性的差异，用人源化小鼠（hu-NSG-SGM3）感染 EBOV 或 RESTV。与人类感染时疾病的差异一致，仅在感染 EBOV 的小鼠中观察到明显的体重减轻以及肝损伤和疾病的标志物。这些异常与肝脏中 EBOV 复制水平显著升高相关，但脾脏中并无此现象，提示在该模型中，感染早期特定组织中病毒复制的效率可能与病毒致病性的差异有关。
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