Mayo Clinic School of Medicine, Rochester, MN.
Women's Health Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, MN.
Menopause. 2018 Apr;25(4):391-398. doi: 10.1097/GME.0000000000001020.
The aim of the study was to determine the association between self-reported vasomotor symptoms (VMS) and obstructive sleep apnea (OSA) risk.
The STOP-BANG to evaluate OSA and Menopause Rating Scale (MRS) were administered to 2,935 women seen in the Women's Health Clinic at Mayo Clinic in Rochester, MN, between May 2015 and December 2016. Of these, 1,691 women were included in the analysis. Total MRS and VMS ratings were compared using logistic regression, with age, smoking, and body mass index (BMI) included as covariates between women at intermediate/high risk versus low risk for OSA.
Total MRS scores were significantly higher in women with intermediate/high-risk OSA scores versus those with low-risk scores [mean (SD): 16.8 (8.0) vs 12.9 (7.0), P < 0.001]. Women at intermediate/high OSA risk were older, had more education, self-reported hypertension, BMI >35 kg/m, and were less likely to be married or employed. Self-reported severe/very severe VMS were significantly associated with intermediate/high risk versus low risk for OSA (26.6% vs 15.0%; P < 0.001). After adjusting for age, BMI, smoking status, and self-reported hypertension, the odds of having intermediate/high risk for OSA were 1.87 times higher for those with severe/very severe VMS compared with those with none/mild/moderate VMS (95% CI, 1.29-2.71, P < 0.001). This association persisted upon subgroup analysis based on BMI <25 kg/m (odds ratio 2.15; 95% CI, 1.12-4.16, P = 0.022).
Self-reported severe/very severe VMS were associated with intermediate/high risk for OSA in midlife women, even in women with BMI <25 kg/m. Given the limitations of the STOP-BANG tool, OSA risk may, however, have been overestimated.
本研究旨在探讨自述血管舒缩症状（VMS）与阻塞性睡眠呼吸暂停（OSA）风险之间的关联。
2015 年 5 月至 2016 年 12 月，在明尼苏达州罗切斯特市梅奥诊所的妇女健康诊所就诊的 2935 名女性中，使用 STOP-BANG 评估 OSA 和绝经评定量表（MRS）进行评估。其中，1691 名女性纳入分析。采用逻辑回归比较总 MRS 和 VMS 评分，在中间/高 OSA 风险与低 OSA 风险女性之间，将年龄、吸烟和体重指数（BMI）作为协变量。
中间/高 OSA 评分女性的总 MRS 评分明显高于低 OSA 评分女性[平均（SD）：16.8（8.0）比 12.9（7.0），P＜0.001]。中间/高 OSA 风险女性年龄较大，受教育程度较高，自述患有高血压，BMI＞35kg/m，已婚或就业的可能性较小。自述严重/非常严重的 VMS 与中间/高 OSA 风险显著相关（26.6%比 15.0%；P＜0.001）。在调整年龄、BMI、吸烟状况和自述高血压后，严重/非常严重 VMS 的女性发生中间/高 OSA 的风险是无/轻度/中度 VMS 女性的 1.87 倍（95%CI，1.29-2.71，P＜0.001）。基于 BMI＜25kg/m 的亚组分析中，该关联仍然存在（比值比 2.15；95%CI，1.12-4.16，P=0.022）。
在中年女性中，自述严重/非常严重的 VMS 与中间/高 OSA 风险相关，即使在 BMI＜25kg/m 的女性中也是如此。鉴于 STOP-BANG 工具的局限性，OSA 风险可能被高估。
