Pitkänen A, Jolkkonen J, Sirviö J, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Peptides. 1988;9 Suppl 1:105-7. doi: 10.1016/0196-9781(88)90232-x.
Kindling was induced in Sprague-Dawley rats by repeated injection of pentylenetetrazol (PTZ, 30 mg/kg, IP). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr-somatostatin binding were measured in different areas of the brain in saline-injected controls, rats receiving PTZ but not kindled (prekindled rats), and kindled rats. Compared to SLI levels in controls, SLI increased (p < 0.01) in the frontal cortex, striatum (p < 0.05 in kindled rats), and hippocampus of both prekindled and kindled animals. Hypothalamic levels of SLI remained unchanged. Compared with the controls, no change was found in somatostatin receptor binding in the frontal cortex, striatum or hippocampus in prekindled or kindled animals. These results suggest that an increased level of somatostatin may be connected to the development and maintenance of kindling.
通过反复腹腔注射戊四氮（PTZ，30毫克/千克）在斯普拉格-道利大鼠中诱导点燃效应。在注射生理盐水的对照组、接受PTZ但未点燃的大鼠（预点燃大鼠）和点燃大鼠的大脑不同区域测量生长抑素样免疫反应性（SLI）和125I-酪氨酸-生长抑素结合。与对照组的SLI水平相比，预点燃和点燃动物的额叶皮质、纹状体（点燃大鼠中p < 0.05）和海马体中的SLI增加（p < 0.01）。下丘脑的SLI水平保持不变。与对照组相比，预点燃或点燃动物的额叶皮质、纹状体或海马体中的生长抑素受体结合未发现变化。这些结果表明，生长抑素水平的升高可能与点燃效应的发展和维持有关。
