Pitkänen A, Sirviö J, Jolkkonen J, Riekkinen P
Neuropeptides. 1986 Jan;7(1):63-71. doi: 10.1016/0143-4179(86)90080-6.
Wistar rats were injected with a convulsant doze of pentylenetetrazol (PTZ) (50 mg/kg, i.p.). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in various brain areas immediately after PTZ injection, after the first head twitches, and 15 minutes, 1 h, 4 h, and 24 h after generalized tonic-clonic convulsions. SLI tended to decrease in the striatum (p less than 0.02), frontal cortex, hippocampus, and hypothalamus 1 hour after convulsion. Specific somatostatin binding remained stable. According to our results, somatostatin is not connected to initiation or spread of seizure but may play some role in depressing seizures.
给Wistar大鼠腹腔注射惊厥剂量的戊四氮（PTZ）（50毫克/千克）。在注射PTZ后立即、首次出现头部抽搐后以及全身强直阵挛性惊厥后15分钟、1小时、4小时和24小时，测量不同脑区的生长抑素样免疫反应性（SLI）和125I-Tyr11-生长抑素结合情况。惊厥后1小时，纹状体（p小于0.02）、额叶皮质、海马体和下丘脑的SLI有下降趋势。生长抑素特异性结合保持稳定。根据我们的结果，生长抑素与癫痫发作的起始或传播无关，但可能在抑制癫痫发作中发挥一定作用。
