Oxford Transplant Centre, Nuffield Department of Surgical Science, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LE, UK.
Br Med Bull. 2017 Dec 1;124(1):171-179. doi: 10.1093/bmb/ldx039.
The aim of this review is to bring pancreatic transplantation out of the specialist realm, informing practitioners about this important procedure, so that they feel better equipped to refer suitable patients for transplantation and manage, counsel and support when encountering them within their own speciality.
Narrative review conducted in May 2017. OVID interface searching EMBASE and MEDLINE databases, using Timeframe: Inception to June 1, 2017. Articles were assessed for clinical relevance and most up to date content with articles written in english as the only inclusion criteria. Other sources, used included conference proceedings/presentations, unpublished data from our institution (Oxford Transplant Centre).
Pancreas transplantation has evolved from an experimental procedure to the gold standard of care for patients with type 1 diabetes and uraemia. Currently, it remains the most effective method of establishing and maintaining euglycemia over the longer term, halting and potentially reversing many of the secondary complications associated with diabetes. Significant improvements to quality of life and better life expectancy make it in the longer term, a lifesaving procedure compared to waiting candidates.
The future of solid organ pancreas transplantation remains uncertain, with extensive comorbidity and advances in alternative therapies makes the long-term growth of the procedure questionable.
Therapies to alleviate problems associated with ischaemia reperfusion injury, graft pancreatitis and more effective monitoring methods for detecting and treating organ rejection are the key areas of growth.
本综述旨在将胰腺移植从专业领域中呈现出来，使从业者了解这一重要的手术，从而使他们在遇到适合移植的患者时，更有能力进行转诊，并在自己的专业领域内对患者进行管理、咨询和支持。
2017 年 5 月进行的叙述性综述。通过 OVID 界面在 EMBASE 和 MEDLINE 数据库中进行搜索，时间范围为：起始日期至 2017 年 6 月 1 日。评估文章的临床相关性和最新内容，纳入标准为仅使用英文撰写的文章。还使用了其他来源，包括会议记录/演讲、我们机构（牛津移植中心）的未发表数据。
胰腺移植已从实验性手术发展为 1 型糖尿病和尿毒症患者的护理金标准。目前，它仍然是在较长时间内建立和维持血糖正常的最有效方法，可以阻止并可能逆转与糖尿病相关的许多继发性并发症。生活质量的显著改善和更长的预期寿命使它在长期来看成为一种比等待候选者更具挽救生命的手术。
实体器官胰腺移植的未来仍不确定，广泛的合并症和替代治疗方法的进步使得该手术的长期发展受到质疑。
缓解与缺血再灌注损伤、移植物胰腺炎相关的问题的治疗方法，以及更有效的监测方法以检测和治疗器官排斥反应，是关键的增长点。
