Nuffield Department of Surgical Sciences and Oxford Transplant Centre, University of Oxford and Oxford University Hospitals NHS Trust, UK.
Nuffield Department of Surgical Sciences and Oxford Transplant Centre, University of Oxford and Oxford University Hospitals NHS Trust, UK.
Am J Med. 2016 Jul;129(7):667-73. doi: 10.1016/j.amjmed.2016.02.011. Epub 2016 Mar 8.
Diabetes is the pandemic disease of the modern era, with 10% of these patients having type 1 diabetes mellitus. Despite the prevalence, morbidities, and associated financial burden, treatment options have not changed since the introduction of injectable insulin. To date, over 40,000 pancreas transplants have been performed globally. It remains the only known method for restoring glycemic control and thus curing type 1 diabetes mellitus. The aim of this review is to bring pancreatic transplantation out of the specialist realm, informing practitioners about this important procedure, so that they feel better equipped to refer suitable patients for transplantation and manage, counsel, and support when encountering them within their own specialty. This study was a narrative review conducted in October 2015, with OVID interface searching EMBASE and MEDLINE databases, using Timeframe: Inception to October 2015. Articles were assessed for clinical relevance and most up-to-date content, with articles written in English as the only inclusion criterion. Other sources used included conference proceedings/presentations and unpublished data from our institution (Oxford Transplant Centre). Pancreatic transplantation is growing and has quickly become the gold standard of care for patients with type 1 diabetes mellitus and renal failure. Significant improvements in quality of life and life expectancy make pancreatic transplant a viable and economically feasible intervention. It remains the most effective method of establishing and maintaining euglycemia, halting and potentially reversing complications associated with diabetes.
糖尿病是现代社会的一种流行病，其中 10%的患者患有 1 型糖尿病。尽管这种疾病发病率高、危害性大且相关经济负担重，但自注射用胰岛素问世以来，治疗选择并未改变。迄今为止，全球已进行了超过 40000 例胰腺移植。这仍然是恢复血糖控制、从而治愈 1 型糖尿病的唯一已知方法。本综述的目的是将胰腺移植从专科领域中带出来，让从业者了解这一重要手术，以便他们更有信心地将合适的患者转介接受移植，并在自己的专业领域中遇到这些患者时，能够更好地进行管理、咨询和支持。本研究是 2015 年 10 月进行的叙述性综述，通过 OVID 界面在 EMBASE 和 MEDLINE 数据库中进行搜索，时间范围为：起始至 2015 年 10 月。评估了文章的临床相关性和最新内容，仅纳入以英语撰写的文章。还使用了会议记录/演示文稿和我们机构（牛津移植中心）的未发表数据等其他来源。胰腺移植正在发展，已迅速成为肾衰竭 1 型糖尿病患者的护理金标准。生活质量和预期寿命的显著提高使胰腺移植成为一种可行且经济上可行的干预措施。它仍然是建立和维持正常血糖、阻止和可能逆转与糖尿病相关的并发症的最有效方法。
