Nuffield Department of Surgical Sciences, Oxford, UK; Oxford Centre of Diabetes, Endocrinology and Metabolism, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
Diabet Med. 2014 May;31(5):512-21. doi: 10.1111/dme.12373.
Since the first pancreas transplants in the early 1960s, whole-organ pancreas transplantation, either alone or combined with kidney transplantation, has become commonplace in many countries around the world. Whole-organ pancreas transplantation is available in the UK, with ~200 transplants currently carried out per year. Patient survival and pancreas graft outcome rates are now similar to other solid organ transplant programmes, with high rates of long-term insulin independence. In the present review, we will discuss whole-pancreas transplantation as a treatment for diabetes, focusing on indications for transplantation, the nature of the procedure performed, graft survival rates and the consequences of pancreas transplantation on metabolic variables and the progression of diabetes-related complications.
自 20 世纪 60 年代初首例胰腺移植以来，在全球许多国家，单纯胰腺移植或联合肾移植已成为常规治疗手段。英国可开展全胰腺移植，每年约进行 200 例移植。目前，患者存活率和胰腺移植物的效果与其他实体器官移植方案相似，长期胰岛素独立性高。在本综述中，我们将讨论全胰腺移植作为糖尿病的治疗方法，重点讨论移植适应证、手术方式、移植物存活率以及胰腺移植对代谢变量和糖尿病相关并发症进展的影响。
