Tokudome S, Tokunaga O, Shimamoto Y, Miyamoto Y, Sumida I, Kikuchi M, Takeshita M, Ikeda T, Fujiwara K, Yoshihara M
Department of Community Health Science, Saga Medical School, Japan.
Cancer Res. 1989 Jan 1;49(1):226-8.
Using a population-based cancer registry, we tabulated 69 definite adult T-cell leukemia/lymphoma cases (36 males and 33 females) and 2.20 expected cases (0.95 for males and 1.25 for females) diagnosed from 1981 to 1983 in Saga, Japan. The number of human T-lymphotropic virus type I carriers was computed by applying sex- and age-specific anti-human T-lymphotropic virus type I antibody positive rates among blood donors at the blood center in 1986 to the whole population of Saga Prefecture in 1982. The age-specific incidence rates among male human T-lymphotropic virus type I carriers from 40 to 79 yr of age per 100,000 were significantly higher than those of female carriers (P less than 0.05), and the rates from 60 to 69 yr of age were the highest in both sexes. The annual crude incidence rates among carriers were 115.9 for males and 66.4 for females. The summary incidence rates with 95% confidence intervals were 115.9 (58.4 to 193.0) for males and 65.9 (30.0 to 115.9) for females. The cumulative risks were 4.5% (0.8 to 11.0) for males and 2.6% (0.3 to 7.0) for females. These morbidity figures were assumed to be underestimated partly due to the newly proposed clinical entity of adult T-cell leukemia/lymphoma.
利用基于人群的癌症登记系统，我们统计了1981年至1983年在日本佐贺诊断出的69例确诊成人T细胞白血病/淋巴瘤病例（36例男性和33例女性）以及2.20例预期病例（男性0.95例，女性1.25例）。通过将1986年血液中心献血者中按性别和年龄划分的抗人类T淋巴细胞病毒I型抗体阳性率应用于1982年佐贺县的全部人口，计算出人类T淋巴细胞病毒I型携带者的数量。40至79岁男性人类T淋巴细胞病毒I型携带者每10万人中的年龄别发病率显著高于女性携带者（P<0.05），60至69岁年龄段的发病率在两性中均为最高。携带者中的年粗发病率男性为115.9，女性为66.4。95%置信区间的汇总发病率男性为115.9（58.4至193.0），女性为65.9（30.0至115.9）。累积风险男性为4.5%（0.8至11.0），女性为2.6%（0.3至7.0）。这些发病率数据部分被认为因新提出的成人T细胞白血病/淋巴瘤临床实体而被低估。
