Zou Yuanyuan, Zhang Xi, Zhang Jingyi, Ji Xiangning, Liu Yuqing, Zhao Shaozhen
Department of Refraction and Cornea, Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, China.
The Second Department of Ophthalmology, Cangzhou Central Hospital, Cangzhou, China.
Braz J Med Biol Res. 2019 Apr 8;52(4):e8217. doi: 10.1590/1414-431X20198217.
The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done. Through the association test of overall meta-analysis, we did not observe a significant difference between RVO cases and controls under the A vs G (allele) (z=1.49, P=0.137), A vs G (carrier) (z=1.42, P =0.155), GA vs GG (z=1.50, P=0.135), and GA+AA vs GG (z=1.50, P=0.135). Furthermore, we observed similar negative results in the association test of subgroup analysis (all P>0.05). Heterogeneity, Begg's, and Egger's tests excluded the presence of high heterogeneity and publication bias. Statistically stable results were observed in the sensitivity analyses. Based on integrated analysis of the current evidence, Prothrombin gene G20210A polymorphism is likely unrelated to the risk of RVO.
本研究的目的是进行一项更新的荟萃分析，以定量研究凝血酶原基因G20210A多态性与视网膜静脉阻塞（RVO）风险之间的关联，该关联基于现有结果不一致的出版物。我们使用Stata软件进行异质性检验、关联性检验、Begg检验和Egger检验以及敏感性分析。我们检索了三个在线数据库（PubMed、Embase和WOS），共获得422篇文章。根据我们的选择标准，最终有24项病例对照研究纳入了这项总体荟萃分析；并按种族、对照来源和RVO类型等因素进行了亚组分析。通过总体荟萃分析的关联性检验，我们未观察到RVO病例与对照在A与G（等位基因）（z=1.49，P=0.137）、A与G（携带者）（z=1.42，P =0.155）、GA与GG（z=1.50，P=0.135）以及GA+AA与GG（z=1.50，P=0.135）之间存在显著差异。此外，我们在亚组分析的关联性检验中也观察到了类似的阴性结果（所有P>0.05）。异质性检验、Begg检验和Egger检验排除了高异质性和发表偏倚的存在。在敏感性分析中观察到了统计学上稳定的结果。基于对当前证据的综合分析，凝血酶原基因G20210A多态性可能与RVO风险无关。
