Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk.

OBJECTIVE

Present meta-analysis was performed to investigate the role of stromal cell-derived factor () gene rs1801157 polymorphism in systemic lupus erythematosus (SLE).

RESULTS

Five publications with 1,087 cases and 1,181 controls were incorporated in this meta-analysis. Overall, a marginal association between rs1801157 polymorphism and reduced SLE risk was found under GA vs. GG model (OR = 0.84, 95% CI = 0.70-1.00). A similar result was also observed in Asian subgroup under the same comparison after stratification analysis by ethnicity (OR = 0.79, 95% CI = 0.63-1.00).

MATERIALS AND METHODS

All included studies were retrieved from PubMed, EMBASE, Google Scholar Web and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to appraise the strength of association between rs1801157 polymorphism and SLE risk. The stratification analysis was also performed according to ethnicity. In addition, heterogeneity was examined with Q test, and sensitivity analysis was used to test the stability of final results. Begg's funnel plot and Egger's test were adopted to evaluate publication bias.

CONCLUSIONS

rs1801157 polymorphism may not influence the risk of SLE. However, more studies with larger sample sizes involving different populations are needed to further explore this issue.