系统性红斑狼疮患者血清中巨噬细胞来源趋化因子（MDC）和基质金属蛋白酶-9（MMP-9）水平及其与疾病活动度的关系

Serum Levels of MDC and MMP-9 and the Relationship Between Serum Levels and Disease Activity in the Patients with Systemic Lupus Erythematosus.

作者信息

Liu Yang, Tie Ning, Bai Lijie

机构信息

Yang Liu, PhD Department of Rheumatology, the First Affiliated Hospital, Inner Mongolia Medical University, China.

Ning Tie, M.S Department of Rheumatology, the First Affiliated Hospital, Inner Mongolia Medical University, China.

出版信息

Pak J Med Sci. 2015 Jul-Aug;31(4):803-6. doi: 10.12669/pjms.314.7325.

DOI:10.12669/pjms.314.7325

PMID:26430407

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4590386/

Abstract

BACKGROUND AND OBJECTIVE

Systemic lupus erythematosus (SLE) is a complicated autoimmune disease. Although its pathogenesis is not clear, cytokine may be involved in it. So we investigated serum levels of macrophage-derived chemokine (MDC), and matrix metalloproteinase-9 (MMP-9), and to determine the relationship between serum levels and the disease activity of SLE.

METHODS

Serum levels of MDC and MMP-9 were measured by enzyme-linked immuno sorbent assay (ELISA).

RESULTS

Significantly decreased serum levels of MDC and MMP-9 were found in SLE as compared to those in controls (P<0.001 P<0.001), but serum levels of MDC and MMP-9 increased after treatment (P<0.001 P<0.05). Serum levels of MDC and MMP-9 were lower in patients with active disease than those with inactive disease (P<0.001 P<0.05). Significantly decreased serum levels of MDC and MMP-9 were found in patients with renal damage than those without the damage (P<0.001 P<0.05). Serum level of MDC was lower in patients with arthritis than those without the damage (P<0.001), but serum level of MMP-9 has no significant difference in two groups (P>0.05).

CONCLUSION

The present data suggest that MDC and MMP-9 may be involved in the pathogenesis of SLE, and serum levels of MDC and MMP-9 could be markers of monitoring disease activity, renal damage, disease progression and improvement in SLE.

摘要

背景与目的

系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病。尽管其发病机制尚不清楚，但细胞因子可能参与其中。因此，我们研究了巨噬细胞衍生趋化因子（MDC）和基质金属蛋白酶-9（MMP-9）的血清水平，并确定血清水平与SLE疾病活动度之间的关系。

方法

采用酶联免疫吸附测定（ELISA）法检测血清MDC和MMP-9水平。

结果

与对照组相比，SLE患者血清MDC和MMP-9水平显著降低（P<0.001，P<0.001），但治疗后血清MDC和MMP-9水平升高（P<0.001，P<0.05）。活动期疾病患者的血清MDC和MMP-9水平低于非活动期患者（P<0.001，P<0.05）。有肾脏损害的患者血清MDC和MMP-9水平显著低于无肾脏损害的患者（P<0.001，P<0.05）。有关节炎的患者血清MDC水平低于无关节损害的患者（P<0.001），但两组患者血清MMP-9水平无显著差异（P>0.05）。