Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Departamento de Ciências Básicas, Araçatuba, 16018-805, Brazil.
Univ Estadual Paulista (Unesp), Faculdade de Odontologia, Departamento de Ciências Básicas, Araçatuba, 16018-805, Brazil.
Sci Rep. 2017 Oct 31;7(1):14410. doi: 10.1038/s41598-017-13098-5.
The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females.
本研究旨在通过力量训练（ST）、雷洛昔芬（Ral）或 ST 加 Ral 的联合应用，在女性自然衰老过程中、特别是在围绝经期预防女性骨质疏松症。18-21 月龄的雌性 Wistar 大鼠总共进行了 120 天的 ST，每周进行三次爬梯运动，雷洛昔芬通过灌胃（每天 1mg/kg）给药。评估了骨微结构、面积骨密度、股骨颈骨强度、免疫组织化学、破骨细胞和成骨细胞表面。我们发现这些治疗方法以不同的方式调节骨重塑周期。ST 和 Ral 治疗均导致围绝经期后期大鼠股骨颈骨微结构得到改善。然而，只有 ST 改善了股骨颈皮质微结构和骨强度。因此，我们认为在围绝经期后期进行 ST 是预防女性与年龄相关的骨质疏松症的有效干预措施。
