Ugurlu Erhan, Kilic-Toprak Emine, Can Ilknur, Kilic-Erkek Ozgen, Altinisik Goksel, Bor-Kucukatay Melek
Faculty of Medicine, Department of Pulmonology, Pamukkale University, Denizli, Turkey.
Faculty of Medicine, Department of Physiology, Pamukkale University, Denizli, Turkey.
Can Respir J. 2017;2017:1286263. doi: 10.1155/2017/1286263. Epub 2017 Sep 27.
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations.
The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer.
RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control.
Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial.
慢性阻塞性肺疾病（COPD）的特征是进行性气流受限。已证实心血管相关合并症会导致发病和死亡，尤其是在病情加重期间。本研究的目的是确定新诊断的COPD患者血液流变学（红细胞聚集、变形性）的变化及其对药物治疗的反应，并与病情加重的COPD患者的值进行比较。
该研究包括13例COPD患者、12例对照者和16例病情加重的COPD患者。根据指南确定COPD 的严重程度。用激光衍射血细胞分析仪测量红细胞（RBC）的变形性和聚集性。
与其他组相比，病情加重的COPD患者的RBC变形性降低。病情加重期间测定的COPD患者的红细胞聚集和血浆纤维蛋白原高于对照组。
COPD病情加重时红细胞变形性降低和聚集性增加可能是导致氧合恶化进而使患者临床症状加重的不利机制。改变血液流变学参数的治疗方式可能有益。
