重复经颅磁刺激（rTMS）调节老年人的脂质代谢。
Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Lipid Metabolism in Aging Adults.
作者信息
Ren Weicong, Ma Jiang, Li Juan, Zhang Zhijie, Wang Mingwei
机构信息
Department of Psychology, Hebei Normal University, Shijiazhuang, China.
Key Laboratory of Brain Aging and Cognitive Neuroscience of Hebei Province, Hebei Medical University, Shijiazhuang, China.
出版信息
Front Aging Neurosci. 2017 Oct 17;9:334. doi: 10.3389/fnagi.2017.00334. eCollection 2017.
Abstract
Hyperlipidemia, one of the cardiovascular (CV) risk factors, is associated with an increase in the risk for dementia. Repetitive transcranial magnetic stimulation (rTMS) was applied over the right dorsolateral prefrontal cortex (DLPFC) to modulate serum lipid levels in older adults. Participants received 10 sessions of rTMS or sham stimulation intervention within 2 weeks. The serum lipid and thyroid hormone-related endocrine levels were assessed before and after the treatment. We found that rTMS significantly decreased serum lipid levels, including the total cholesterol (CHO) and triglyceride (TG); meanwhile, it also increased the thyroid-stimulating hormone (TSH) as well as thyroxine (T4) levels. This suggests that rTMS modulated the serum lipid metabolism by altering activity in the hypothalamo-pituitary-thyroid (HPT) axis. The trial was registered on the website of Chinese Clinical Trial Registry (http://www.chictr.org.cn).
摘要
高脂血症是心血管（CV）危险因素之一，与痴呆风险增加有关。对老年人右侧背外侧前额叶皮层（DLPFC）进行重复经颅磁刺激（rTMS）以调节血脂水平。参与者在2周内接受10次rTMS或假刺激干预。在治疗前后评估血脂和甲状腺激素相关内分泌水平。我们发现rTMS显著降低血脂水平，包括总胆固醇（CHO）和甘油三酯（TG）；同时，它还提高了促甲状腺激素（TSH）以及甲状腺素（T4）水平。这表明rTMS通过改变下丘脑 - 垂体 - 甲状腺（HPT）轴的活性来调节血脂代谢。该试验已在中国临床试验注册中心网站（http://www.chictr.org.cn）注册。
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