Feng Zhou, Long Wenmin, Hao Binhan, Ding Ding, Ma Xiaoqing, Zhao Liping, Pang Xiaoyan
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240 China.
Gut Pathog. 2017 Oct 26;9:59. doi: 10.1186/s13099-017-0208-7. eCollection 2017.
is a major member of sulfidogenic bacteria in human gut, it was originally recovered from different clinical specimens of intra-abdominal infections and recently was reported potentially linked to different chronic metabolic disorders. However, there is still insufficient understanding on its detailed function and mechanism to date.
A strain was isolated from fresh feces of a latent autoimmune diabetes in adults patient and we investigated its pathogenicity by oral administration to specific-pathogen-free mice. Tissue samples and serum were collected after sacrifice. Stool samples were collected at different time points to profile the gut microbiota.
infection resulted in the reduction of body weight and fat mass, apparent hepatosplenomegaly and elevated serum inflammatory factors, including serum amyloid A and interleukin-6, while without significant change of the overall gut microbiota structure.
These results demonstrated that higher amount of caused systemic inflammatory response in SPF mice, which adds new evidence to the pathogenicity of this bacterium and implied its potential role to the chronic inflammation related metabolic diseases like diabetes.
是人类肠道中产硫化物细菌的主要成员，最初是从腹腔感染的不同临床标本中分离出来的，最近有报道称其可能与不同的慢性代谢紊乱有关。然而，迄今为止，对其详细功能和机制仍了解不足。
从一名成年潜伏性自身免疫性糖尿病患者的新鲜粪便中分离出一株菌株，通过口服给予无特定病原体小鼠来研究其致病性。处死小鼠后收集组织样本和血清。在不同时间点收集粪便样本以分析肠道微生物群。
感染导致体重和脂肪量减少、明显的肝脾肿大以及血清炎症因子升高，包括血清淀粉样蛋白A和白细胞介素-6，而肠道微生物群的整体结构没有显著变化。
这些结果表明，在无特定病原体小鼠中，较高数量的会引起全身炎症反应，这为该细菌的致病性增添了新证据，并暗示了其在糖尿病等慢性炎症相关代谢疾病中的潜在作用。
