Azizpour Maryam, Hosseini Seyyed Davood, Jafari Parvaneh, Akbary Neda
Department of Microbiology, Arak branch, Islamic Azad University, Arak, Iran.
Razi Vaccine and Serum Research Institute, Arak Branch, Arak, Iran.
Avicenna J Med Biotechnol. 2017 Oct-Dec;9(4):163-168.
Needle free vaccines have a several advantages and very attractive way for vaccination. In a body, mucosal surfaces provide a universal entry portal for all the known and emerging infectious pathogenic microbes. Therefore, it seems, vaccination strategies need to be reorganized for vaccines that are hindering the entry capability of pathogenic microbes through mucosal surfaces. Lactic acid Bacteria (LAB) are widely used in the food industry and at the present, used as delivery vehicles for biological investigations. In this review, we summarized the Results of several studies which () used as a live vector for vaccines. These bacteria are considered as promising candidates for heterologous expression of proteins and biotechnological usage. LAB are considered as promising candidates for heterologous expression of proteins and biotechnological usage. The results showed that these bacteria have an ability to deliver antigen to immune system. Therefore, developing mucosal live vaccines using lactic acid bacterium, , as an antigen delivery vector, is an attractive alternative choice and a safer vaccination strategy against pathogens.
无针疫苗具有诸多优势，是一种非常有吸引力的疫苗接种方式。在人体中，黏膜表面为所有已知的和新出现的感染性致病微生物提供了一个通用的进入门户。因此，对于那些阻碍致病微生物通过黏膜表面进入能力的疫苗，似乎需要重新组织疫苗接种策略。乳酸菌（LAB）在食品工业中广泛应用，目前也被用作生物学研究的递送载体。在这篇综述中，我们总结了几项将其用作疫苗活载体的研究结果。这些细菌被认为是蛋白质异源表达和生物技术应用的有前途的候选者。乳酸菌被认为是蛋白质异源表达和生物技术应用的有前途的候选者。结果表明，这些细菌有能力将抗原递送至免疫系统。因此，开发以乳酸菌作为抗原递送载体的黏膜活疫苗，是一种有吸引力的替代选择，也是一种针对病原体的更安全的疫苗接种策略。
