Lloren Khristine Kaith S, Senevirathne Amal, Lee John Hwa
College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan City, Jeollabuk-do, 54596, Republic of Korea.
Mater Today Bio. 2024 Nov 16;29:101349. doi: 10.1016/j.mtbio.2024.101349. eCollection 2024 Dec.
Advancements in vaccine technology are increasingly focused on leveraging the unique properties of both pathogenic and commensal bacteria. This revolutionary approach harnesses the diverse immune modulatory mechanisms and bacterial biology inherent in different bacterial species enhancing vaccine efficacy and safety. Pathogenic bacteria, known for their ability to induce robust immune responses, are being studied for their potential to be engineered into safe, attenuated vectors that can target specific diseases with high precision. Concurrently, commensal bacteria, which coexist harmlessly with their hosts and contribute to immune system regulation, are also being explored as novel delivery systems and in microbiome-based therapy. These bacteria can modulate immune responses, offering a promising avenue for developing effective and personalized vaccines. Integrating the distinctive characteristics of pathogenic and commensal bacteria with advanced bacterial engineering techniques paves the way for innovative vaccine and therapeutic platforms that could address a wide range of infectious diseases and potentially non-infectious conditions. This holistic approach signifies a paradigm shift in vaccine development and immunotherapy, emphasizing the intricate interplay between the bacteria and the immune systems to achieve optimal immunological outcomes.
疫苗技术的进步越来越聚焦于利用致病细菌和共生细菌的独特特性。这种革命性的方法利用了不同细菌物种固有的多种免疫调节机制和细菌生物学特性，提高了疫苗的效力和安全性。致病细菌以其诱导强烈免疫反应的能力而闻名，目前正在研究将其改造为安全的减毒载体的潜力，这些载体能够高精度地靶向特定疾病。与此同时，与宿主无害共存并有助于免疫系统调节的共生细菌，也正在作为新型递送系统和基于微生物群的疗法进行探索。这些细菌可以调节免疫反应，为开发有效且个性化的疫苗提供了一条有前景的途径。将致病细菌和共生细菌的独特特征与先进的细菌工程技术相结合，为创新的疫苗和治疗平台铺平了道路，这些平台可以应对广泛的传染病以及潜在的非感染性疾病。这种整体方法标志着疫苗开发和免疫疗法的范式转变，强调细菌与免疫系统之间复杂的相互作用以实现最佳的免疫效果。
