Grose Derek, Milroy Robert
Beatson West of Scotland Cancer Centre, Glasgow, Scotland, UK.
Glasgow Royal Infirmary, Glasgow, Scotland, UK.
J Comorb. 2011 Dec 27;1:45-50. doi: 10.15256/joc.2011.1.5. eCollection 2011.
Chronic obstructive pulmonary disease (COPD) is a major burden throughout the world. It is associated with a significantly increased incidence of lung cancer and may influence treatment options and outcome. Impaired lung function confirming COPD is an independent risk factor for lung cancer. Oxidative stress and inflammation may be a key link between COPD and lung cancer, with numerous molecular markers being analysed to attempt to understand the pathway of lung cancer development. COPD negatively influences the ability to deliver radical treatment options, so attempts must be made to look for alternative methods of treating lung cancer, while aiming to manage the underlying COPD. Detailed assessment and management plans utilising the multidisciplinary team must be made for all lung cancer patients with COPD to provide the best care possible. Journal of Comorbidity 2011;1:45-50.
慢性阻塞性肺疾病（COPD）是全球范围内的一项重大负担。它与肺癌发病率的显著上升相关，并且可能影响治疗方案和治疗结果。肺功能受损确诊为COPD是肺癌的一个独立危险因素。氧化应激和炎症可能是COPD与肺癌之间的关键联系，目前正在分析众多分子标志物，以试图了解肺癌的发展途径。COPD对提供根治性治疗方案的能力产生负面影响，因此必须努力寻找治疗肺癌的替代方法，同时致力于控制潜在的COPD。对于所有患有COPD的肺癌患者，必须制定利用多学科团队的详细评估和管理计划，以提供尽可能最佳的护理。《共病杂志》2011年；1：45 - 50。
