脂联素基因rs1052700和FTO基因rs3751812的常见变异与肥胖和2型糖尿病风险
Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes.
作者信息
Saravani Ramin, Galavi Hamid Reza, Noorzehi Nafiseh, Ranjbar Nasrin, Mollashahee-Kohkan Fatemeh
机构信息
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Rep Biochem Mol Biol. 2017 Oct;6(1):80-87.
BACKGROUND
Perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. The FTO gene is associated with type-2 diabetes (T2D) and increased fat mass. In this work the association of and FTO gene polymorphisms in T2D was investigated.
METHODS
One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study. The subjects were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS-PCR) and their clinical traits were analyzed.
RESULTS
A significant association was found between the rs1052700 polymorphism and T2D, and between the FTO rs3751812 polymorphism and obesity (P = 0.03 and 0.003, respectively); however, no significant relationship was found between rs3751812 and T2D.
CONCLUSION
The FTO rs3751812 polymorphism is a major genetic determinant of obesity, but not T2D. The rs1052700 polymorphism is related to T2D but not obesity.
背景
perilipins是一种包裹脂肪细胞中脂质球的蛋白质，脂肪细胞是在脂质储存和分解中起核心作用的类固醇生成细胞。FTO基因与2型糖尿病（T2D）和脂肪量增加有关。在本研究中，调查了 perilipins和FTO基因多态性与T2D的关联。
方法
183名患有T2D的伊朗男性和女性以及174名无已知代谢疾病的健康对照者参与了本研究。使用四引物扩增阻滞突变系统-聚合酶链反应（Tetra-ARMS-PCR）对受试者进行基因分型，并分析他们的临床特征。
结果
perilipins rs1052700多态性与T2D之间以及FTO rs3751812多态性与肥胖之间存在显著关联（P值分别为0.03和0.003）；然而，rs3751812与T2D之间未发现显著关系。
结论
FTO rs3751812多态性是肥胖的主要遗传决定因素，但不是T2D的主要遗传决定因素。perilipins rs1052700多态性与T2D有关，但与肥胖无关。
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