State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210023, China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Hainan 571101, China.
Org Lett. 2017 Nov 17;19(22):6208-6211. doi: 10.1021/acs.orglett.7b03113. Epub 2017 Nov 1.
Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.
两种新型烯二炔衍生天然产物，amycolamycins A 和 B（1 和 2），从一种与蝗虫相关的放线菌 Amycolatopsis sp. HCa4 中得到鉴定。Amycolamycins A 和 B 含有一个独特的 2-(环戊[a]茚-5-基)环氧乙烷核心，具有烯二炔聚酮生物合成起源的嫌疑。acm 生物合成基因簇的测序和分析使我们能够提出 1 和 2 的生物合成途径。此外，amycolamycin A（1）对 M231 乳腺癌细胞系具有选择性细胞毒性。
