1 Radiation Physics and Protection, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 7LE, United Kingdom.
2 Department of Nuclear Medicine, Royal Surrey County Hospital NHS Foundation Trust, Guildford, United Kingdom.
AJR Am J Roentgenol. 2018 Jan;210(1):153-157. doi: 10.2214/AJR.17.18060. Epub 2017 Nov 1.
A study was performed to compare background liver signal-to-noise ratio (SNR) and visually assessed image quality of clinical PET/CT studies from the same PET acquisition data reconstructed by Bayesian penalized likelihood (BPL) and ordered subset expectation maximization (OSEM) over a range of patient weights.
The effect of a BPL PET reconstruction algorithm on liver SNR and visually assessed image quality over a range of patient weights (41-196 kg; n = 108) was retrospectively compared with standard-of-care OSEM reconstruction on the same PET acquisition data after IV administration of F-FDG (4 MBq/kg).
BPL showed no significant change (p > 0.05) in liver SNR with increasing weight and body mass index (BMI), whereas OSEM showed increasing noise with increasing weight and BMI. The liver SNR was significantly higher using BPL than a standard OSEM reconstruction (p < 0.0002 for all BMI groups). Visually assessed image quality declined at a greater rate with increasing weight and BMI in the OSEM images than with BPL images.
BPL provides a more consistent visually assessed image quality and liver background SNR than does OSEM, with the greatest benefit for the heaviest patients.
本研究旨在比较同批 PET 采集数据经贝叶斯惩罚似然（BPL）和有序子集期望最大化（OSEM）重建后，不同体重患者的背景肝脏信噪比（SNR）和临床 PET/CT 图像的视觉评估质量。
回顾性比较了 108 例患者（体重 41-196kg；n=108）静脉注射 F-FDG（4MBq/kg）后，BPL 与标准 OSEM 重建对同批 PET 采集数据的影响。
BPL 重建的肝脏 SNR 随体重和体重指数（BMI）的增加而无显著变化（p＞0.05），而 OSEM 则随体重和 BMI 的增加而噪声增加。与标准 OSEM 重建相比，BPL 重建的肝脏 SNR 显著更高（所有 BMI 组 p＜0.0002）。与 BPL 图像相比，OSEM 图像的肝脏 SNR 随体重和 BMI 的增加而下降的速度更快。
BPL 提供了比 OSEM 更一致的视觉评估图像质量和肝脏背景 SNR，对最重的患者获益最大。
