Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Mato Grosso, Brazil; Curso de Farmácia, Faculdade Noroeste do Mato Grosso, Associação Juinense de Ensino Superior (AJES), Juína, Mato Grosso, Brazil.
Biomed Pharmacother. 2018 Jan;97:143-151. doi: 10.1016/j.biopha.2017.10.073. Epub 2017 Nov 6.
Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a murine ovalbumin (OVA)-induced allergic asthma model. Mice were sensitized to OVA by i.p. injection on days 1st and 10th, followed by a daily challenge with OVA using a nebulizer, from days 19th to 24th. Vitexin or dexamethasone were orally administered 1h before each OVA challenge. Vitexin attenuates migration induced by OVA-hypersensitivity of eosinophil, neutrophil, and mononuclear cells in bronchoalveolar lavage fluid (BALF). Histological analysis of the lungs shows that vitexin suppressed leukocyte infiltration, mucus production and pulmonary edema. Increases in Th2 cytokines in BALF in OVA-induced asthma is also attenuated by vitexin, as well as plasma levels of IgE. Overall, these results suggest that vitexin can suppress OVA-induced allergic inflammation in mice and provide a strong rationale for further developing vitexin as a candidate treatment for allergic hypersensitivity. These data corroborate the popular use of vitexin-rich plants for asthma treatment.
牡荆素是多种药用植物的重要成分，常用于治疗哮喘，如山楂、牡荆、西番莲和水盾草。然而，关于牡荆素作为抗哮喘药物的潜力还没有相关信息。本研究旨在评估牡荆素在卵清蛋白（OVA）诱导的过敏性哮喘模型中的抗敏活性。通过腹腔注射在第 1 天和第 10 天致敏小鼠，然后从第 19 天到第 24 天，使用雾化器每天用 OVA 进行挑战。在每次 OVA 挑战前 1 小时，给予牡荆素或地塞米松进行口服给药。牡荆素可减轻卵清蛋白超敏反应诱导的嗜酸性粒细胞、中性粒细胞和单核细胞在支气管肺泡灌洗液（BALF）中的迁移。肺部组织学分析显示，牡荆素抑制白细胞浸润、粘液产生和肺水肿。牡荆素还可减轻 OVA 诱导的哮喘中 BALF 中 Th2 细胞因子的增加，以及血浆中 IgE 的水平。总的来说，这些结果表明牡荆素可以抑制 OVA 诱导的小鼠过敏性炎症，并为进一步将牡荆素开发为治疗过敏性过敏的候选药物提供了有力的依据。这些数据证实了富含牡荆素的植物在哮喘治疗中的广泛应用。
