氨甲环酸治疗难治性慢性输血依赖性胃肠道血管发育异常出血
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding.
作者信息
Grooteman Karina V, van Geenen Erwin J M, Drenth Joost P H
机构信息
Gastroenterology and Hepatology, Radboudumc, Nijmegen, Netherlands.
出版信息
BMJ Case Rep. 2017 Nov 1;2017:bcr-2017-221832. doi: 10.1136/bcr-2017-221832.
Abstract
A small proportion of gastrointestinal angiodysplasia bleeding leads to chronic blood cell transfusion dependency. There are no guidelines supporting decision-making among various treatments in patients with gastrointestinal angiodysplasia bleeding. When endoscopic argon plasma coagulation is ineffective, the angiogenesis inhibitors thalidomide and octreotide can be considered. We describe a 77-year-old woman who had side effects of these angiogenesis inhibitors, which caused her to have continued bleeding. She was successfully treated with tranexamic acid with a substantial decrease in need for red blood cell transfusions.
摘要
一小部分胃肠道血管发育异常出血会导致慢性血细胞输血依赖。对于胃肠道血管发育异常出血患者，在各种治疗方法之间进行决策时，目前尚无相关指南支持。当内镜下氩离子凝固术无效时，可以考虑使用血管生成抑制剂沙利度胺和奥曲肽。我们描述了一名77岁女性，她出现了这些血管生成抑制剂的副作用，导致持续出血。她通过氨甲环酸成功治疗，红细胞输血需求大幅减少。
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