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社论:单核细胞进入大脑的门户:CXCR7,新的乐团指挥。

Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor.

机构信息

Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA and

Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

出版信息

J Leukoc Biol. 2017 Nov;102(5):1155-1157. doi: 10.1189/jlb.3CE0717-273R.

DOI:10.1189/jlb.3CE0717-273R
PMID:29093133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5636043/
Abstract

Discussion on the potential role for CXCR7 as a major signaling pathway for CD14CD16 monocyte transmigration across the blood brain barrier, and its therapeutic application for NeuroAIDS.

摘要

探讨 CXCR7 作为 CD14CD16 单核细胞穿越血脑屏障的主要信号通路的潜在作用及其在神经艾滋病治疗中的应用。

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Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor.社论:单核细胞进入大脑的门户:CXCR7,新的乐团指挥。
J Leukoc Biol. 2017 Nov;102(5):1155-1157. doi: 10.1189/jlb.3CE0717-273R.
2
Differential effects of CXCR4-CXCL12- and CXCR7-CXCL12-mediated immune reactions on murine P0106-125 -induced experimental autoimmune neuritis.CXCR4-CXCL12和CXCR7-CXCL12介导的免疫反应对小鼠P0106-125诱导的实验性自身免疫性神经炎的不同影响。
Neuropathol Appl Neurobiol. 2013 Dec;39(7):772-87. doi: 10.1111/nan.12039.
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CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4.CXCR7介导神经祖细胞向CXCL12迁移,且不依赖于CXCR4。
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The peculiarities of the SDF-1/CXCL12 system: in some cells, CXCR4 and CXCR7 sing solos, in others, they sing duets.基质细胞衍生因子-1/CXCL12 系统的特点:在某些细胞中,趋化因子受体 4 和 7 独唱,而在其他细胞中,它们则二重唱。
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本文引用的文献

1
Frontline Science: CXCR7 mediates CD14CD16 monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS.前沿科学:CXCR7介导CD14CD16单核细胞穿越血脑屏障:神经艾滋病的潜在治疗靶点。
J Leukoc Biol. 2017 Nov;102(5):1173-1185. doi: 10.1189/jlb.3HI0517-167R. Epub 2017 Jul 28.
2
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.稳态和全身炎症状态下人类单核细胞亚群的命运与寿命。
J Exp Med. 2017 Jul 3;214(7):1913-1923. doi: 10.1084/jem.20170355. Epub 2017 Jun 12.
3
Substance P-mediated chemokine production promotes monocyte migration.P物质介导的趋化因子产生促进单核细胞迁移。
J Leukoc Biol. 2017 Apr;101(4):967-973. doi: 10.1189/jlb.1AB0416-188RR. Epub 2016 Oct 21.
4
Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection.单核细胞和内皮细胞黏附分子表达改变与人类免疫缺陷病毒感染中的血管炎症相关。
Open Forum Infect Dis. 2016 Oct 15;3(4):ofw224. doi: 10.1093/ofid/ofw224. eCollection 2016 Oct.
5
Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status.血液边缘区B细胞频率的波动可能反映与HIV-1疾病进展状态相关的迁移模式。
PLoS One. 2016 May 20;11(5):e0155868. doi: 10.1371/journal.pone.0155868. eCollection 2016.
6
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.在临界可切除和局部晚期胰腺癌患者中,使用CCR2抑制剂联合FOLFIRINOX靶向肿瘤相关巨噬细胞:一项单中心、开放标签、剂量探索、非随机的1b期试验。
Lancet Oncol. 2016 May;17(5):651-62. doi: 10.1016/S1470-2045(16)00078-4. Epub 2016 Apr 4.
7
CCR2 on CD14(+)CD16(+) monocytes is a biomarker of HIV-associated neurocognitive disorders.CCR2 在 CD14(+)CD16(+)单核细胞上的表达是 HIV 相关神经认知障碍的生物标志物。
Neurol Neuroimmunol Neuroinflamm. 2014 Oct 9;1(3):e36. doi: 10.1212/NXI.0000000000000036. eCollection 2014 Oct.
8
Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers.趋化因子的平衡:维持中枢神经系统屏障的内环境稳定与保护作用
Front Cell Neurosci. 2014 May 28;8:154. doi: 10.3389/fncel.2014.00154. eCollection 2014.
9
CXCR7 influences the migration of B cells during maturation.CXCR7 影响 B 细胞在成熟过程中的迁移。
Eur J Immunol. 2014 Mar;44(3):694-705. doi: 10.1002/eji.201343907. Epub 2014 Feb 19.
10
Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis.HIV 进入中枢神经系统的机制:HIV 感染的 CD14+CD16+单核细胞对 CCL2 的敏感性增加,以及 CCR2、JAM-A 和 ALCAM 在穿越血管内皮细胞中的关键作用。
PLoS One. 2013 Jul 26;8(7):e69270. doi: 10.1371/journal.pone.0069270. Print 2013.