Inoue Takashi, Matsumura Yuji, Araki Osamu, Karube Yoko, Maeda Sumiko, Kobayashi Satoru, Chida Masayuki
Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan.
Department of Cardiothoracic Surgery, Dokkyo Koshigaya Hospital, Koshigaya, Saitama, Japan.
Ann Thorac Cardiovasc Surg. 2018 Feb 20;24(1):1-5. doi: 10.5761/atcs.oa.17-00088. Epub 2017 Oct 31.
In the present study, we examined the relationship between intraoperative pleural lavage cytology findings and presence of epidermal growth factor receptor (EGFR) gene mutations.
We investigated 160 patients who underwent surgical treatment for primary lung adenocarcinoma at our hospital from January 2011 to December 2013 to determine the presence of EGFR gene mutations and pleural lavage cytology.
In all, 52 subjects (31.5%) were positive EGFR gene mutations, of whom 38 were found to possess the Exon 21 L858R mutation. Intraoperative pleural lavage cytology examinations were performed in 160 subjects and 12 had positive results, of whom 6 were positive for EGFR gene mutations, which was the Exon 21 L858R mutation in all. In a comparison between subjects possessing the Exon 21 L858R mutation and those negative for EGFR gene mutations, lavage cytology-positive (p = 0.02) and vascular infiltration-negative (p = 0.01) were characteristics of the Exon 21 L868R mutation-positive group.
Subjects positive for the EGFR Exon 21 L858R mutation had a higher positive rate of intraoperative pleural lavage cytology than those not possessing EGFR mutations.
在本研究中，我们检测了术中胸膜腔灌洗细胞学检查结果与表皮生长因子受体（EGFR）基因突变之间的关系。
我们调查了2011年1月至2013年12月期间在我院接受原发性肺腺癌手术治疗的160例患者，以确定EGFR基因突变情况和胸膜腔灌洗细胞学检查结果。
共有52例受试者（31.5%）EGFR基因突变呈阳性，其中38例存在外显子21 L858R突变。对160例受试者进行了术中胸膜腔灌洗细胞学检查，12例结果呈阳性，其中6例EGFR基因突变呈阳性，且均为外显子21 L858R突变。在比较存在外显子21 L858R突变的受试者与EGFR基因突变阴性的受试者时，灌洗细胞学检查阳性（p = 0.02）和无血管浸润（p = 0.01）是外显子21 L868R突变阳性组的特征。
EGFR外显子21 L858R突变阳性的受试者术中胸膜腔灌洗细胞学检查的阳性率高于未发生EGFR突变的受试者。
