Department of Medicine, University of California, San Diego, La Jolla, USA.
Department of Pathology, University of California, San Diego, La Jolla, USA.
J Gastroenterol. 2018 Jan;53(1):6-17. doi: 10.1007/s00535-017-1404-4. Epub 2017 Nov 1.
The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis. Significant understanding of HSCs has been achieved using rodent models and isolated murine HSCs; as well as investigating human liver tissues and human HSCs. There is growing interest and need of translating rodent study findings to human HSCs and human liver diseases. However, species-related differences impose challenges on the translational research. In this review, we focus on the current information on human HSCs isolation methods, human HSCs markers, and established human HSC cell lines.
肝脏星状细胞（HSCs）位于肝脏的 Disse 间隙中，具有多种功能。它们被认为是肝纤维化的主要贡献者。使用啮齿动物模型和分离的鼠 HSCs 以及研究人类肝组织和人类 HSCs，已经对 HSCs 有了重要的了解。人们越来越有兴趣和需要将啮齿动物研究的发现转化为人类 HSCs 和人类肝脏疾病。然而，种属相关的差异给转化研究带来了挑战。在这篇综述中，我们重点介绍了目前关于人类 HSCs 分离方法、人类 HSCs 标志物和已建立的人类 HSC 细胞系的信息。
