1 The K.G. Jebsen Center for Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway.
2 Clinic of Cardiology, St Olav's Hospital, Norway.
Eur J Prev Cardiol. 2018 Oct;25(15):1646-1652. doi: 10.1177/2047487318784365. Epub 2018 Jun 25.
Background Atrial fibrillation is the most common heart rhythm disorder, and high body mass index is a well-established risk factor for atrial fibrillation. The objective of this study was to examine the associations of physical activity and body mass index and risk of atrial fibrillation, and the modifying role of physical activity on the association between body mass index and atrial fibrillation. Design The design was a prospective cohort study. Methods This study followed 43,602 men and women from the HUNT3 study in 2006-2008 until first atrial fibrillation diagnosis or end of follow-up in 2015. Atrial fibrillation diagnoses were collected from hospital registers and validated by medical doctors. Cox proportional hazard regression analysis was performed to assess the association between physical activity, body mass index and atrial fibrillation. Results During a mean follow-up of 8.1 years (352,770 person-years), 1459 cases of atrial fibrillation were detected (4.1 events per 1000 person-years). Increasing levels of physical activity were associated with gradually lower risk of atrial fibrillation ( p trend 0.069). Overweight and obesity were associated with an 18% (hazard ratio 1.18, 95% confidence interval 1.03-1.35) and 59% (hazard ratio 1.59, 95% confidence interval 1.37-1.84) increased risk of atrial fibrillation, respectively. High levels of physical activity attenuated some of the higher atrial fibrillation risk in obese individuals (hazard ratio 1.53, 95% confidence interval 1.03-2.28 in active and 1.96, 95% confidence interval 1.44-2.67 in inactive) compared to normal weight active individuals. Conclusion Overweight and obesity were associated with increased risk of atrial fibrillation. Physical activity offsets some, but not all, atrial fibrillation risk associated with obesity.
心房颤动是最常见的心律失常，而高体重指数是心房颤动的一个既定危险因素。本研究的目的是研究体力活动和体重指数与心房颤动风险的关系，以及体力活动对体重指数与心房颤动之间关系的修饰作用。
这是一项前瞻性队列研究。
本研究随访了 2006-2008 年 HUNT3 研究中的 43602 名男性和女性，直至 2015 年首次发生心房颤动或随访结束。心房颤动的诊断是通过医院的登记册收集并由医生进行验证的。采用 Cox 比例风险回归分析评估体力活动、体重指数与心房颤动之间的关系。
在平均 8.1 年（352770 人年）的随访期间，共检测到 1459 例心房颤动（4.1 例/1000 人年）。体力活动水平的升高与心房颤动风险的逐渐降低相关（趋势 P 值为 0.069）。超重和肥胖与心房颤动风险分别增加 18%（风险比 1.18，95%置信区间 1.03-1.35）和 59%（风险比 1.59，95%置信区间 1.37-1.84）。高体力活动水平减轻了肥胖个体中较高的心房颤动风险的一部分（与正常体重的活跃个体相比，活跃个体的风险比为 1.53，95%置信区间为 1.03-2.28，不活跃个体的风险比为 1.96，95%置信区间为 1.44-2.67）。
超重和肥胖与心房颤动风险增加有关。体力活动减轻了部分但不是全部与肥胖相关的心房颤动风险。
