Chen Haihui, Wu Mengxin, Li Guisheng, Hua Li, Chen Shaojun, Huang Haixin
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
Medicine (Baltimore). 2017 Nov;96(44):e8202. doi: 10.1097/MD.0000000000008202.
To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy.The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade ≥2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182-4.582). No significant difference was observed in the degree of acute radiation oral mucositis injury among the patients with different genotypes (P = .449, 95% CI: 0.691-2.304). Multivariate analysis showed that N stage and genotype were significantly associated with acute radiation dermatitis of Grade ≥2 (OR = 3.221, P < .001, 95% CI: 1.669-6.216, OR = 2.860, P = .006, 95% CI: 1.354-6.043). T stage and smoking status were significantly associated with acute radiation oral mucositis with Grade ≥2 (OR = 2.508, P = .001, 95% CI: 1.427-4.408, OR = 6.355, P < .001, 95% CI: 2.533-15.841).The XRCC1 codon 399 genotype in NPC could be an important predicting factor in the risk of acute radiation dermatitis during IMRT.
探讨X射线修复交叉互补基因1（XRCC1）密码子399单核苷酸多态性（SNP）与接受调强放射治疗（IMRT）的鼻咽癌（NPC）患者急性放射性皮炎和口腔黏膜炎的相关性。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测114例NPC患者放疗前XRCC1密码子399的SNP。携带Arg/Arg基因型的患者发生≥2级急性放射性皮炎的风险高于其他2种基因型（P = 0.014，95%CI：1.182 - 4.582）。不同基因型患者的急性放射性口腔黏膜炎损伤程度无显著差异（P = 0.449，95%CI：0.691 - 2.304）。多因素分析显示，N分期和基因型与≥2级急性放射性皮炎显著相关（OR = 3.221，P < 0.001，95%CI：1.669 - 6.216，OR = 2.860，P = 0.006，95%CI：1.354 - 6.043）。T分期和吸烟状态与≥2级急性放射性口腔黏膜炎显著相关（OR = 2.508，P = 0.001，95%CI：1.427 - 4.408，OR = 6.355，P < 0.001，95%CI：2.533 - 15.841）。NPC患者的XRCC1密码子399基因型可能是IMRT期间急性放射性皮炎风险的重要预测因素。
