Benzeid Rajaa, Gihbid Amin, Tawfik Nezha, Benchakroun Nadia, Bendahhou Karima, Benider Abdellatif, Guensi Amal, Benna Naima El, Maltouf Abdelkarim Filali, Mzibri Mohammed El, Attaleb Mohammed, Khyatti Meriem, Chaoui Imane
Biology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Laboratory of Microbiology and Molecular Biology, Faculty of Sciences, Rabat, Morocco.
Contemp Oncol (Pozn). 2023;27(1):28-34. doi: 10.5114/wo.2023.127307. Epub 2023 Apr 27.
Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy in nasopharyngeal cancer (NPC). In NPC patients, previous research has studied the association between X-ray repair cross-complementing group 1 and 3 (XRCC1 and XRCC3) polymorphisms and radio-therapeutic response. The objective of our study was to test the association between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and the response to radiotherapy in the NPC Moroccan population.
A total of 100 patients with NPC were genotyped for polymorphisms in XRCC1 and XRCC3 genes.
The results revealed that the genotypes and alleles of both SNPs did not show any significant association with clinical stages (for XRCC1 Arg399Gln: [genotype] = 0.559; [allele] = 0.440) and (for XRCC3 Thr241Met: [genotype] = 0.638; [allele] = 0.567). Moreover, in the study of the association between the polymorphisms and radiotherapy, the response to radiation therapy between genotypes and alleles was not statistically significant (for XRCC1 Arg399Gln p [genotype] = 0.583; p [allele] = 0.459) and (for XRCC3 Thr241Met [genotype] = 0.660; [allele] = 0.590).
The present study suggests that XRCC1 Arg399Gln polymorphism does not have any impact on the radio-therapeutic response in Moroccan NPC patients whereas XRCC3 Thr241Met polymorphism may act as a prognostic indicator for NPC patients treated with radiotherapy. However, studies with a larger sample are needed to confirm our results.
DNA修复基因中的单核苷酸多态性（SNP）主要与鼻咽癌（NPC）的放疗反应相关。在NPC患者中，先前的研究已经探讨了X射线修复交叉互补基因1和3（XRCC1和XRCC3）多态性与放射治疗反应之间的关联。我们研究的目的是检测XRCC1 Arg399Gln和XRCC3 Thr241Met多态性与摩洛哥NPC人群放疗反应之间的关联。
共对100例NPC患者进行了XRCC1和XRCC3基因多态性的基因分型。
结果显示，两个SNP的基因型和等位基因与临床分期均无显著关联（对于XRCC1 Arg399Gln：[基因型]=0.559；[等位基因]=0.440）以及（对于XRCC3 Thr241Met：[基因型]=0.638；[等位基因]=0.567）。此外，在多态性与放疗之间的关联研究中，基因型和等位基因之间的放疗反应无统计学意义（对于XRCC1 Arg399Gln，p[基因型]=0.583；p[等位基因]=0.459）以及（对于XRCC3 Thr241Met，[基因型]=0.660；[等位基因]=0.590）。
本研究表明，XRCC1 Arg399Gln多态性对摩洛哥NPC患者的放疗反应没有任何影响，而XRCC3 Thr241Met多态性可能作为接受放疗的NPC患者的预后指标。然而，需要更大样本量的研究来证实我们的结果。
