Le Reste Jean Yves, Nabbe Patrice, Billot Grasset Alice, Le Floch Bernard, Grall Pauline, Derriennic Jeremy, Odorico Michele, Lalande Sophie, le Goff Delphine, Barais Marie, Chiron Benoit, Lingner Heidrun, Guillou Morgane, Barraine Pierre
EA 7479 SPURBO, Department of general practice, Université de Bretagne occidentale, Brest, France.
Allgemein Medizin Hochschule Hannover, Hannover, Germany.
PLoS One. 2017 Nov 2;12(11):e0186931. doi: 10.1371/journal.pone.0186931. eCollection 2017.
The European General Practitioners Research Network (EGPRN) designed and validated a comprehensive definition of multimorbidity using a systematic literature review and qualitative research throughout Europe. This definition was tested as a model to assess death or acute hospitalization in multimorbid outpatients.
To assess which criteria in the EGPRN concept of multimorbidity could detect outpatients at risk of death or acute hospitalization in a primary care cohort at a 6-month follow-up and to assess whether a large scale cohort with FPs would be feasible.
Family Physicians included a random sample of multimorbid patients who attended appointments in their offices from July to December 2014. Inclusion criteria were those of the EGPRN definition of Multimorbidity. Exclusion criteria were patients under legal protection and those unable to complete the 2-year follow-up. Statistical analysis was undertaken with uni- and multivariate analysis at a 6-month follow-up using a combination of approaches including both automatic classification and expert decision making. A Multiple Correspondence Analysis (MCA) completed the process with a projection of illustrative variables. A logistic regression was finally performed in order to identify and quantify risk factors for decompensation.
19 FPs participated in the study. 96 patients were analyzed. 3 different clusters were identified. MCA showed the central function of psychosocial factors and peaceful versus conflictual relationships with relatives in all clusters. While taking into account the limit of a small cohort, age, frequency of family physician visits and extent of family difficulties were the factors which predicted death or acute hospitalization.
A large scale cohort seems feasible in primary care. A sense of alarm should be triggered to prevent death or acute hospitalization in multimorbid older outpatients who have frequent family physician visits and who experience family difficulties.
欧洲全科医生研究网络(EGPRN)通过全欧洲的系统文献综述和定性研究,设计并验证了一个关于多重疾病的综合定义。该定义作为一个模型进行了测试,以评估患有多种疾病的门诊患者的死亡或急性住院情况。
评估EGPRN多重疾病概念中的哪些标准能够在6个月随访时检测出初级保健队列中存在死亡或急性住院风险的门诊患者,并评估建立一个由家庭医生组成的大规模队列是否可行。
家庭医生纳入了2014年7月至12月在其诊所就诊的多重疾病患者的随机样本。纳入标准为EGPRN多重疾病定义中的标准。排除标准为受法律保护的患者以及无法完成2年随访的患者。在6个月随访时,采用包括自动分类和专家决策在内的多种方法进行单变量和多变量分析。多重对应分析(MCA)通过对说明性变量的投影完成了这一过程。最后进行逻辑回归以识别和量化失代偿的风险因素。
19名家庭医生参与了该研究。对96名患者进行了分析。识别出3个不同的聚类。MCA显示了心理社会因素以及在所有聚类中与亲属的和睦关系与冲突关系的核心作用。在考虑到小队列的局限性的情况下,年龄、家庭医生就诊频率和家庭困难程度是预测死亡或急性住院的因素。
在初级保健中建立大规模队列似乎是可行的。对于那些频繁就诊于家庭医生且经历家庭困难的患有多种疾病的老年门诊患者,应触发警报以预防死亡或急性住院。