Bae S-C, Lee Y H
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Division of Rheumatology, Seoul, Korea.
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):74-79. doi: 10.14715/cmb/2017.63.10.12.
The present study aimed to systemically review the evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and systemic lupus erythematosus (SLE), as well as the associations between several polymorphisms in the MIF gene and SLE susceptibility. We performed a meta-analysis of serum/plasma levels of MIF in SLE patients and controls and evaluated evidence of associations between the MIF -173 C/G allele and -794CATT5-8 polymorphisms and the associated risk for SLE. Nine studies were included in this meta-analysis. Meta-analysis indicated that MIF levels were significantly higher in the SLE group than in the control group (SMD = 1.154, 95% CI = 0.369-1.938, P = 0.004). Stratification by ethnicity showed significantly higher MIF levels in the SLE group representing Asian populations (SMD = 1.911, 95% CI = 0.871-2.951, P < 0.001). MIF levels were significantly higher in the SLE group than in the control group in the age-and/or sex matched population, but not in the unmatched population (SMD = 1.236, 95% CI = 0.579-1.893, P < 0.001; SMD = 1.118, 95% CI = -0.027-2.263, P = 0.056). However, results of the meta-analysis showed no association between SLE and the MIF -173 C allele, the -794CATT7 allele, and the -794CATT7-MIF-173C haplotype with high heterogeneity. Our meta-analysis demonstrated significantly higher circulating MIF levels in patients with SLE, but no evidence of associations between MIF -173 C/G and -794CATT5-8 polymorphisms and SLE susceptibility.
本研究旨在系统评价有关循环巨噬细胞移动抑制因子（MIF）水平与系统性红斑狼疮（SLE）之间关系的证据，以及MIF基因中几种多态性与SLE易感性之间的关联。我们对SLE患者和对照组血清/血浆中MIF水平进行了荟萃分析，并评估了MIF -173 C/G等位基因和 -794CATT5-8多态性与SLE相关风险之间关联的证据。本荟萃分析纳入了9项研究。荟萃分析表明，SLE组的MIF水平显著高于对照组（标准化均数差 = 1.154，95%置信区间 = 0.369 - 1.938，P = 0.004）。按种族分层显示，代表亚洲人群的SLE组MIF水平显著更高（标准化均数差 = 1.911，95%置信区间 = 0.871 - 2.951，P < 0.001）。在年龄和/或性别匹配的人群中，SLE组的MIF水平显著高于对照组，但在未匹配人群中并非如此（标准化均数差 = 1.236，95%置信区间 = 0.579 - 1.893，P < 0.001；标准化均数差 = 1.118，95%置信区间 = -0.027 - 2.263，P = 0.056）。然而，荟萃分析结果显示SLE与MIF -173 C等位基因、-794CATT7等位基因以及具有高度异质性的 -794CATT7-MIF-173C单倍型之间无关联。我们的荟萃分析表明，SLE患者循环MIF水平显著更高，但没有证据表明MIF -173 C/G和 -794CATT5-8多态性与SLE易感性之间存在关联。
