寻找 MyoD 及其经验教训。
Finding MyoD and lessons learned along the way.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA, 02115, United States.
出版信息
Semin Cell Dev Biol. 2017 Dec;72:3-9. doi: 10.1016/j.semcdb.2017.10.021. Epub 2017 Nov 1.
Abstract
In 1987, Robert Davis, Hal Weintraub and I reported the identification of MyoD, a transcription factor that could reprogram fibroblasts into skeletal muscle cells. In this recollection, I both summarize the prior work of Helen Blau, Woody Wright, Peter Jones and Charlie Emerson that inspired my entry into this field, and the subsequent events that led to finding MyoD. Lastly, I highlight some of the principles in developmental biology that have emerged during the past 30 years, which are particularly relevant to skeletal muscle biology.
摘要
1987 年，我与罗伯特·戴维斯（Robert Davis）、哈尔·温特劳布（Hal Weintraub）共同报道了肌球蛋白重链（MyoD）的鉴定，该转录因子可将成纤维细胞重编程为骨骼肌细胞。在这篇回忆中，我总结了海伦·布洛（Helen Blau）、伍迪·赖特（Woody Wright）、彼得·琼斯（Peter Jones）和查理·爱默生（Charlie Emerson）的前期工作，这些工作激发了我进入该领域，以及随后发现 MyoD 的事件。最后，我强调了过去 30 年来在发育生物学中出现的一些原则，这些原则与骨骼肌生物学特别相关。
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