CSIRO, Black Mountain, GPO Box 1700, Acton, ACT 2601, Australia.
CSIRO, Black Mountain, GPO Box 1700, Acton, ACT 2601, Australia.
J Struct Biol. 2018 Jan;201(1):76-83. doi: 10.1016/j.jsb.2017.10.012. Epub 2017 Oct 31.
Sequence-definable polymers are seen as a prerequisite for design of future materials, with many polymer scientists regarding such polymers as the holy grail of polymer science. Recombinant proteins are sequence-defined polymers. Proteins are dictated by DNA templates and therefore the sequence of amino acids in a protein is defined, and molecular biology provides tools that allow redesign of the DNA as required. Despite this advantage, proteins are underrepresented in materials science. In this publication we investigate the advantages and limitations of using proteins as templates for rational design of new materials.
序列定义聚合物被视为设计未来材料的前提条件，许多聚合物科学家将此类聚合物视为聚合物科学的圣杯。重组蛋白是序列定义的聚合物。蛋白质由 DNA 模板决定，因此蛋白质中氨基酸的序列是定义的，分子生物学提供了允许根据需要重新设计 DNA 的工具。尽管具有这种优势，但蛋白质在材料科学中的代表性不足。在本出版物中，我们研究了将蛋白质用作模板进行新材料的合理设计的优势和局限性。
