Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Sci Rep. 2017 Nov 2;7(1):14973. doi: 10.1038/s41598-017-14721-1.
Parkinson disease (PD) is associated with multiple factors, including iron, which is demonstrated to deposit excessively in PD brains. We detected iron deposition by susceptibility weighted image (SWI) and measured the levels of iron metabolism-related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum of PD patients and control subjects. Clinical symptoms of PD were evaluated by series of rating scales. Relationships among above factors were analyzed. Results showed that corrected phase (CP) value of substantia nigra (SN) was significantly decreased in PD group compared to control group, hence, SN was the main region with excessive iron deposition. In PD group, ferritin was significantly elevated in CSF and reduced in serum compared to control group, and levels of ferritin in CSF and serum were both significantly and positively correlated with CP value of SN, thus, abnormal iron metabolism in central and peripheral systems was associated with iron deposition. CP value of SN in PD group was significantly and negatively correlated with interleukin-1β level in CSF, so interleukin-1β might be a neuroinflammatory factor produced by excessive iron in SN. Iron deposition in SN was significantly correlated with motor symptoms and part of non-motor symptoms of PD.
帕金森病（PD）与多种因素有关，包括铁，铁被证明在 PD 大脑中过度沉积。我们通过磁敏感加权成像（SWI）检测铁沉积，并测量 PD 患者和对照组的脑脊液（CSF）和血清中铁代谢相关蛋白和炎症因子的水平。通过一系列评分量表评估 PD 的临床症状。分析了上述因素之间的关系。结果表明，与对照组相比，PD 组黑质（SN）的校正相位（CP）值显著降低，因此 SN 是铁过度沉积的主要区域。在 PD 组中，CSF 中的铁蛋白明显升高，血清中降低，且 CSF 和血清中的铁蛋白水平与 SN 的 CP 值均呈显著正相关，因此，中枢和外周系统的异常铁代谢与铁沉积有关。PD 组 SN 的 CP 值与 CSF 中的白细胞介素-1β水平呈显著负相关，因此白细胞介素-1β可能是 SN 中过量铁产生的神经炎症因子。SN 中的铁沉积与 PD 的运动症状和部分非运动症状显著相关。
