运动心脏中的 C/EBPB-CITED4。
C/EBPB-CITED4 in Exercised Heart.
机构信息
Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong, 226001, China.
State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
出版信息
Adv Exp Med Biol. 2017;1000:247-259. doi: 10.1007/978-981-10-4304-8_14.
C/EBPB is a crucial transcription factor, participating in a variety of biological processes including cell proliferation, differentiation and development. In the cardiovascular system, C/EBPB-CITED4 signaling is known as a signaling pathway mediating exercise-induced cardiac growth. After its exact role in exercised heart firstly reported in 2010, more and more evidence confirmed that. MicroRNA (e.g. miR-222) and many molecules (e.g. Alpha-lipoic acid) can regulate this pathway and then involve in the cardiac protection effect induced by endurance exercise training. In addition, in cardiac growth during pregnancy, C/EBPB is also a required regulator. This chapter will give an introduction of the C/EBPB-CITED4 signaling and the regulatory network based on this signaling pathway in exercised heart.
C/EBPB 是一种关键的转录因子，参与多种生物学过程，包括细胞增殖、分化和发育。在心血管系统中，C/EBPB-CITED4 信号被认为是介导运动诱导的心脏生长的信号通路。自 2010 年首次报道其在运动心脏中的确切作用以来，越来越多的证据证实了这一点。微小 RNA（例如 miR-222）和许多分子（例如α-硫辛酸）可以调节该通路，从而参与耐力运动训练诱导的心脏保护作用。此外，在妊娠期间的心脏生长中，C/EBPB 也是必需的调节剂。本章将介绍 C/EBPB-CITED4 信号及其在运动心脏中的信号通路的调节网络。
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