Krongvorakul Jatupon, Auparakkitanon Saranya, Trakulsrichai Satariya, Sanguanwit Pitsucha, Sueajai Jetjamnong, Noumjad Nantida, Wananukul Winai
Division of Toxicology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
Ramathibodi Poison Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
J Forensic Sci. 2018 Jul;63(4):1325-1330. doi: 10.1111/1556-4029.13684. Epub 2017 Nov 3.
Human xylazine poisoning is uncommon. This report describes the use of xylazine for intentional poisoning with criminal intent. Two incidents occurred within 3 weeks: the first involved one victim, and the second involved two victims. The clinical presentations were brief coma, bradycardia, hypotension, and hyperglycemia. The victims recalled having been given a drink from a stranger in a hospital waiting room before loss of consciousness. In the first case, general drug screening by gas chromatography/mass spectrometry (MS) revealed xylazine in the gastric contents, but liquid chromatography-tandem MS (LC-MS/MS) of serum did not. In the second incident, LC-MS/MS screening of both victims' urine and serum samples revealed an unknown peak in the total ion chromatograms, which a molecular mass database identified as morantel or xylazine. The latter was confirmed by comparison with a xylazine standard. Based on this report, we suggest that xylazine should be classified as a controlled drug.
人类赛拉嗪中毒并不常见。本报告描述了出于犯罪意图故意使用赛拉嗪进行中毒的情况。在3周内发生了两起事件：第一起涉及一名受害者，第二起涉及两名受害者。临床表现为短暂昏迷、心动过缓、低血压和高血糖。受害者回忆说，在失去意识之前，他们在医院候诊室里喝了一个陌生人给的饮料。在第一起案件中，通过气相色谱/质谱法（MS）进行的一般药物筛查在胃内容物中发现了赛拉嗪，但血清的液相色谱-串联质谱法（LC-MS/MS）检测未发现。在第二起事件中，对两名受害者的尿液和血清样本进行的LC-MS/MS筛查在总离子色谱图中发现了一个未知峰，一个分子量数据库将其鉴定为噻嘧啶或赛拉嗪。通过与赛拉嗪标准品比较，后者得到了证实。基于本报告，我们建议将赛拉嗪归类为管制药物。
