来自牛心朴子的两种新 C 甾体苷的结构测定
Structure determination of two new C steroidal glycosides from Cynanchum komarovii.
作者信息
Zhao Dan, Tang Ming-Xu, Su Shan-Shan, Lu Xiao-Jie, Wang Yu-Bo, Chen Shao-Fei, Wang Hai-Feng, Chen Gang, Pei Yue-Hu
机构信息
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
出版信息
J Asian Nat Prod Res. 2018 Sep;20(9):852-859. doi: 10.1080/10286020.2017.1396977. Epub 2017 Nov 3.
Two new 13,14:14,15-disecopregnane-type C steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3-6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC values being 6.2 and 17.6 μM, respectively, compared to the positive control 5-fluorouracil (6.4 μM).
从白首乌（萝藦科）全草的95%乙醇提取物中获得了两种新的13,14:14,15-二裂孕甾烷型C甾体糖苷，即白首乌苷R（1）和S（2），以及四种已知化合物（3 - 6）。基于一维、二维核磁共振光谱数据和酸水解对新化合物的结构进行了阐明。与阳性对照5-氟尿嘧啶（6.4 μM）相比，化合物1和2对人白血病细胞系（HL-60）显示出强效抑制活性，IC值分别为6.2和17.6 μM。
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