淋巴细胞功能相关抗原-1（LFA-1）和细胞间黏附分子-1（ICAM-1）在癌症中的作用。
Role of LFA-1 and ICAM-1 in Cancer.
作者信息
Reina Manuel, Espel Enric
机构信息
Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.
Celltec UB, Faculty of Biology, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain.
出版信息
Cancers (Basel). 2017 Nov 3;9(11):153. doi: 10.3390/cancers9110153.
Abstract
The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αβ₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia. Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.
摘要
淋巴细胞功能相关抗原-1（LFA-1）（也称为CD11a/CD18和αβ₂），只是人体众多整合素之一，但其重要性源于它仅存在于白细胞中。在本综述中，我们通过淋巴细胞和髓样细胞对肿瘤细胞的作用，总结了将LFA-1及其主要配体细胞间黏附分子-1（ICAM-1，即CD54）与癌症相关联的研究。我们思考LFA-1如何介导白细胞与肿瘤的相互作用以及ICAM-1在肿瘤动态变化中的作用，而这一作用可能独立于其与LFA-1的相互作用。我们还更详细地研究了LFA-1在B细胞慢性淋巴细胞白血病中的作用。最后，我们讨论携带LFA-1的外泌体在肿瘤生长和转移中所起的作用。
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Role of LFA-1 and ICAM-1 in Cancer.淋巴细胞功能相关抗原-1（LFA-1）和细胞间黏附分子-1（ICAM-1）在癌症中的作用。
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