Wang Xue Feng, Ge Tong Tong, Fan Jie, Yang Wei, Cui Ran Ji
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, People's Republic of China.
Oncotarget. 2017 Sep 1;8(44):78225-78233. doi: 10.18632/oncotarget.20606. eCollection 2017 Sep 29.
A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms.
一系列证据表明，神经肽P物质（SP）作为速激肽家族的一员，参与了情绪行为、焦虑、疼痛和炎症反应。最近，SP被认为与癫痫易感性有关，提示其可能具有促惊厥作用。事实上，人们发现一种特定的SP受体——神经激肽-1受体的拮抗剂能够减轻 kainic 酸（KA）诱导的癫痫活动。然而，SP在癫痫中的调控详细机制仍不清楚。在这篇综述中，我们总结了当前的文献，阐述了SP在癫痫中的作用，并为潜在机制提供了假设。
