Department of Clinical Physiology and Exercise, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, UJM and PRES University of Lyon, EA 4607 SNA-EPIS, 42000 Saint-Étienne, France; Institut Hélio-Marin de la côte d'Azur-Réadaptation cognitive, 83400 Hyères, France.
Department of Clinical Physiology and Exercise, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, UJM and PRES University of Lyon, EA 4607 SNA-EPIS, 42000 Saint-Étienne, France.
Rev Neurol (Paris). 2017 Dec;173(10):637-644. doi: 10.1016/j.neurol.2017.05.009. Epub 2017 Nov 1.
The aim of this study was to determine whether cognitive reserve in the elderly affects the evolution of cognitive performance and what its relationship is with active lifestyles in later life.
Cognitive performance was evaluated at baseline and 8 years later in 543 participants of the PROOF cohort, initially aged 67 years. Subjects were categorized as Cognitively Elite (CE), Cognitively Normal (CN) or Cognitively Impaired (CI) at each evaluation. At follow-up, demographic data and lifestyle, including social, intellectual and physical behaviors, were collected by questionnaires.
As much as 69% (n=375) remained unchanged, while 25.5% (n=138) decreased and 5.5% (n=30) improved. When present, the reduction in cognitive status was most often limited to one level, but was dependent on the initial level, affecting up to 73% of the initially CN, but only 58% of the initially CE. Cognitive stability was significantly associated with the degree of social engagement at follow-up (CE: P=0.009; CN: P=0.025).
In the healthy elderly, high cognitive ability predicts both cognitive ability and social involvement in later life. Cognitive decline by only one level may also extend the time to reach impairment, underlining the importance of the so-called cognitive reserve.
本研究旨在确定老年人的认知储备是否会影响认知表现的演变，以及其与晚年积极生活方式的关系。
在 PROOF 队列中，对 543 名最初年龄为 67 岁的参与者进行了认知表现评估，基线评估和 8 年后再次评估。在每次评估中，受试者分为认知精英（CE）、认知正常（CN）或认知受损（CI）。随访时，通过问卷调查收集人口统计学数据和生活方式，包括社会、智力和身体行为。
多达 69%（n=375）保持不变，25.5%（n=138）下降，5.5%（n=30）改善。当存在时，认知状态的下降通常仅限于一个级别，但取决于初始水平，影响高达 73%的初始 CN，但仅影响 58%的初始 CE。认知稳定性与随访时的社会参与程度显著相关（CE：P=0.009；CN：P=0.025）。
在健康的老年人中，较高的认知能力既可以预测认知能力，也可以预测晚年的社会参与度。认知能力仅下降一个级别也可能延长达到损伤的时间，这突显了所谓认知储备的重要性。
Zotero 插件