Nordenstam G, Andersson B, Bengtsson C, Briles D, Scott G, Svanborg A, Svanborg Edén C
Department of Clinical Immunology, Göteborg University, Sweden.
Am J Epidemiol. 1989 Jan;129(1):89-96. doi: 10.1093/oxfordjournals.aje.a115127.
It has been proposed that immunity declines with age. Most evidence for this hypothesis has been obtained from cross-sectional samples of unrelated populations that differ in age, antigen exposure, and morbidity. In the present study, the authors used serum samples collected repeatedly from the same persons in longitudinal studies. Two representative samples of the population in Göteborg, Sweden were obtained; the first was studied at ages 38, 50, and 62 years, and the second at ages 70, 75, 79, and 81 years, respectively. The phosphorylcholine determinant of pneumococcal teichoic acid and the B blood group determinant were selected as model polysaccharide antigens. The results demonstrate a consistent decline in individual antibody levels in the decades before age 70 years but not later. Antibodies to phosphorylcholine and blood group B were highly parallel, suggesting that the decline was a general phenomenon for antibodies to polysaccharide antigens.
有人提出免疫力会随着年龄的增长而下降。这一假设的大部分证据来自于不同年龄、抗原暴露情况和发病率的无关人群的横断面样本。在本研究中，作者使用了纵向研究中从同一人群反复采集的血清样本。获得了瑞典哥德堡人群的两个代表性样本；第一个样本在38岁、50岁和62岁时进行研究，第二个样本分别在70岁、75岁、79岁和81岁时进行研究。肺炎球菌壁磷壁酸的磷酸胆碱决定簇和B血型决定簇被选为模型多糖抗原。结果表明，在70岁之前的几十年里，个体抗体水平持续下降，但70岁之后则不然。针对磷酸胆碱和B血型的抗体高度平行，表明这种下降是多糖抗原抗体的普遍现象。
