日本市售流感快速诊断检测的反应性和敏感性。
Reactivity and sensitivity of commercially available influenza rapid diagnostic tests in Japan.
作者信息
Sakai-Tagawa Yuko, Yamayoshi Seiya, Kawakami Chiharu, Le Mai Q, Uchida Yuko, Saito Takehiko, Nidom Chairul A, Humaira Ira, Toohey-Kurth Kathy, Arafa Abdel-Satar, Liu Ming-Tsan, Shu Yuelong, Kawaoka Yoshihiro
机构信息
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yokohama City Institute of Public Health, Kanagawa, Japan.
出版信息
Sci Rep. 2017 Nov 3;7(1):14483. doi: 10.1038/s41598-017-14536-0.
Abstract
Seasonal influenza virus routinely causes epidemic infections throughout the world. Sporadic infections by H5N1, H5N6, and H7N9 viruses are also reported. To treat patients suffering from such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs) are required. Here, we examined the reactivity and sensitivity of 25 IRDTs available in Japan for the detection of seasonal H1N1pdm09, H3N2, and type B viruses, as well as highly pathogenic H5 and H7 viruses. All of the IRDTs tested detected the seasonal viruses and H5 and H7 viruses albeit with different sensitivities. Several IRDTs detected the H5 and H7 viruses and the seasonal viruses with similar (high) sensitivity.
摘要
季节性流感病毒通常在全球引发流行性感染。也有关于H5N1、H5N6和H7N9病毒散发性感染的报道。为了治疗患有此类病毒感染的患者，需要广泛反应性和高灵敏度的流感快速诊断测试（IRDT）。在此，我们检测了日本现有的25种IRDT对季节性H1N1pdm09、H3N2和B型病毒以及高致病性H5和H7病毒的反应性和灵敏度。所有测试的IRDT均能检测出季节性病毒以及H5和H7病毒，尽管灵敏度有所不同。有几种IRDT检测H5和H7病毒以及季节性病毒时具有相似（高）的灵敏度。
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