Zhu Wenfei, Zhou Jianfang, Li Zi, Yang Lei, Li Xiyan, Huang Weijuan, Zou Sumei, Chen Wenbing, Wei Hejiang, Tang Jing, Liu Liqi, Dong Jie, Wang Dayan, Shu Yuelong
National Institute for Viral Disease Control and Prevention, China Centers for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
These authors contributed equally to this work.
Euro Surveill. 2017 May 11;22(19). doi: 10.2807/1560-7917.ES.2017.22.19.30533.
With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype.
甲型H7N9禽流感病毒在家禽中致病性无或低，但却在人类中引发了严重感染。在当前的第五波疫情中，出现了一种高致病性禽流感（HPAI）H7N9病毒。血凝素（HA）裂解位点插入的四个氨基酸（KRTA）使该病毒具有不依赖胰蛋白酶的感染性。尽管保持了对两种受体的结合偏好，但其HA抗原性与低致病性甲型H7N9禽流感不同。神经氨酸酶的R292K替换赋予了多重耐药表型。
