肠道-骨骼信号传导的免疫学
Immunology of Gut-Bone Signaling.
作者信息
Collins Fraser L, Schepper Jonathan D, Rios-Arce Naiomy Deliz, Steury Michael D, Kang Ho Jun, Mallin Heather, Schoenherr Daniel, Camfield Glen, Chishti Saima, McCabe Laura R, Parameswaran Narayanan
机构信息
Department of Physiology, Michigan State University, East Lansing, MI, USA.
Comparative Medicine and Integrative Biology Program, East Lansing, MI, USA.
出版信息
Adv Exp Med Biol. 2017;1033:59-94. doi: 10.1007/978-3-319-66653-2_5.
Abstract
In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.
摘要
近年来，胃肠道与骨骼健康之间的联系开始受到广泛关注。肠道微生物群的失调与许多与骨质流失相关的疾病的病理过程有关。此外，用益生菌调节肠道微生物群已显示出具有有益的局部和全身作用。在本章中，我们将讨论肠道和骨骼免疫系统，探讨肠道疾病如何影响免疫系统，并研究这些病理变化如何对骨骼健康产生不利影响。
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