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大鼠外周神经系统髓磷脂蛋白的免疫细胞化学定位:P2蛋白并非所有外周神经系统髓鞘的组成成分。

Immunocytochemical localization of rat peripheral nervous system myelin proteins: P2 protein is not a component of all peripheral nervous system myelin sheaths.

作者信息

Trapp B D, McIntyre L J, Quarles R H, Sternberger N H, Webster H D

出版信息

Proc Natl Acad Sci U S A. 1979 Jul;76(7):3552-6. doi: 10.1073/pnas.76.7.3552.

DOI:10.1073/pnas.76.7.3552
PMID:291024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383866/
Abstract

Specific antibodies have been developed against P1, P2, and P0 myelin proteins and were used to study the localization of these proteins in the rat peripheral nervous system. Both peripheral and central nervous system myelin sheaths contain P1 protein. P0 and P2 proteins are found exclusively in peripheral nervous system myelin sheaths. Antisera to P1 and P0 proteins stain all peripheral nervous system myelin sheaths uniformly. P2 protein is not a component of all peripheral nervous system myelin sheaths. In sheaths that do contain P2 protein, it is concentrated in the area of the Schmidt-Lanterman incisures.

摘要

已经开发出针对P1、P2和P0髓磷脂蛋白的特异性抗体,并用于研究这些蛋白在大鼠外周神经系统中的定位。外周和中枢神经系统的髓鞘都含有P1蛋白。P0和P2蛋白仅在外周神经系统的髓鞘中发现。针对P1和P0蛋白的抗血清均匀地染色所有外周神经系统的髓鞘。P2蛋白不是所有外周神经系统髓鞘的组成成分。在确实含有P2蛋白的髓鞘中,它集中在施密特-兰特尔曼切迹区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/67fc2a81d4b1/pnas00007-0521-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/677aa766816e/pnas00007-0518-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/964551ac8593/pnas00007-0519-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/67fc2a81d4b1/pnas00007-0521-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/677aa766816e/pnas00007-0518-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/964551ac8593/pnas00007-0519-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1680/383866/67fc2a81d4b1/pnas00007-0521-a.jpg

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本文引用的文献

1
Studies on the "incisures" of Schmidt and Lanterman.关于施密特切迹和兰特尔曼切迹的研究。
J Cell Sci. 1970 May;6(3):767-91. doi: 10.1242/jcs.6.3.767.
2
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
3
Protein composition of myelin of the peripheral nervous system.外周神经系统髓磷脂的蛋白质组成。
Antioxid Redox Signal. 2022 Sep;37(7-9):560-577. doi: 10.1089/ars.2021.0155. Epub 2022 Apr 26.
4
Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice.低温电子显微镜、X 射线衍射和原子模拟揭示了形成超分子髓鞘样脂蛋白晶格的决定因素。
J Biol Chem. 2020 Jun 26;295(26):8692-8705. doi: 10.1074/jbc.RA120.013087. Epub 2020 Apr 7.
5
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism.髓鞘脂肪事实:脂质和脂肪酸代谢概述。
Cells. 2020 Mar 27;9(4):812. doi: 10.3390/cells9040812.
6
Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.神经调节蛋白 1 型 III 可改善先天性髓鞘少突神经病变小鼠模型的周围神经髓鞘形成。
Hum Mol Genet. 2019 Apr 15;28(8):1260-1273. doi: 10.1093/hmg/ddy420.
7
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins.一种人类髓磷脂蛋白P2门户区域突变体的结构与动力学表明脂肪酸结合蛋白中β桶的开放。
BMC Struct Biol. 2018 Jun 25;18(1):8. doi: 10.1186/s12900-018-0087-2.
8
The Role of Peripheral Myelin Protein 2 in Remyelination.外周髓鞘蛋白 2 在髓鞘修复中的作用。
Cell Mol Neurobiol. 2018 Mar;38(2):487-496. doi: 10.1007/s10571-017-0494-0. Epub 2017 Apr 26.
9
Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.通过中子散射测量人髓磷脂外周膜蛋白P2的动力学——野生型蛋白与铰链突变体的比较
PLoS One. 2015 Jun 11;10(6):e0128954. doi: 10.1371/journal.pone.0128954. eCollection 2015.
10
Structural and functional characterization of human peripheral nervous system myelin protein P2.人周围神经系统髓鞘蛋白 P2 的结构和功能特性。
PLoS One. 2010 Apr 22;5(4):e10300. doi: 10.1371/journal.pone.0010300.
J Neurochem. 1973 Apr;20(4):1207-16. doi: 10.1111/j.1471-4159.1973.tb00089.x.
4
Myelin embedded in polymerized glutaraldehyde-urea.
J Ultrastruct Res. 1972 Oct;41(1):115-32. doi: 10.1016/s0022-5320(72)90042-1.
5
Immunochemical measurement of myelin basic protein in developing rat brain: an index of myelin synthesis.
Dev Biol. 1976 Mar;49(1):294-9. doi: 10.1016/0012-1606(76)90276-1.
6
The visualization of concanavalin-A binding sites in the interperiod line of rat sciatic nerve myelin.
J Neurochem. 1975 Feb;24(2):233-5. doi: 10.1111/j.1471-4159.1975.tb11870.x.
7
Topographical arrangement of membrane proteins in the intact myelin sheath. Lactoperoxidase incorproation of iodine into myelin surface proteins.
J Biol Chem. 1975 Feb 10;250(3):1099-105.
8
Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane.
Biochim Biophys Acta. 1976 Dec 14;455(3):806-16. doi: 10.1016/0005-2736(76)90050-x.
9
Potential of Schwann cells from unmyelinated nerves to produce myelin: a quantitative ultrastructural and radiographic study.无髓神经施万细胞产生髓磷脂的潜力:一项定量超微结构和影像学研究。
J Neurocytol. 1976 Oct;5(8):565-73. doi: 10.1007/BF01175570.
10
Organization of membrane proteins in the intact myelin sheath. Pyridoxal phosphate and salicylaldehyde as probes of myelin structure.
J Biol Chem. 1976 Aug 10;251(15):4729-35.