Rohrer Guido, Höglinger Günter U, Levin Johannes
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Department of Neurology, Technical University Munich, Munich, Germany.
Auton Neurosci. 2018 May;211:26-30. doi: 10.1016/j.autneu.2017.10.006. Epub 2017 Oct 27.
Multiple system atrophy is a progressive neurodegenerative disease characterized by the association of autonomic failure and a movement disorder that consist of either a hypokinetic movement disorder or a cerebellar syndrome or both. In addition to these core characteristics other movement disorders (e.g. dystonia, myoclonus, spasticity), and neuropsychiatric symptoms (e.g. depression, cognitive dysfunction) may occur in the course of the disease and can severely impair patients' quality of live. To date no causal therapy is available and therefore symptomatic treatment plays a pivotal role in patient care. In this article we provide an overview of frequent clinical symptoms and their symptomatic treatment options.
多系统萎缩是一种进行性神经退行性疾病，其特征是自主神经功能衰竭与运动障碍相关联，运动障碍包括运动减少性运动障碍或小脑综合征，或两者兼具。除了这些核心特征外，其他运动障碍（如肌张力障碍、肌阵挛、痉挛）和神经精神症状（如抑郁、认知功能障碍）可能在疾病过程中出现，并可能严重损害患者的生活质量。迄今为止，尚无因果性治疗方法，因此对症治疗在患者护理中起着关键作用。在本文中，我们概述了常见的临床症状及其对症治疗选择。
